The prognostic and predictive value of tumor infiltrating Macrophage and Neutrophil in patient with clear cell renal cell carcinoma: Tumor infiltrating lymphocytes in renal cell carcinoma.
The prognostic and predictive value of tumor infiltrating Macrophage and Neutrophil in patient with clear cell renal cell carcinoma: Tumor infiltrating lymphocytes in renal cell carcinoma.
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DOI：
10.1097/md.0000000000023181
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发表时间：
2020-11-13
期刊：
影响因子：
1.6
通讯作者：
Gu M
中科院分区：
文献类型：
--
作者：
Xu W;Jiang X;Guan C;Gu M
肾细胞癌（RCC）是影响人类的主要癌症;然而，肿瘤浸润淋巴细胞（TIL）与RCC患者预后之间的关系相对未报道。本研究旨在探讨肾癌中TIL、临床病理特征和患者预后之间的关系。这项回顾性研究评估了2004年至2015年期间在癌症基因组图谱中登记的533例透明细胞肾细胞癌（ccRCC）患者。我们从Cancer Immunome Atlas数据库下载了ccRCC患者的免疫细胞类型绝对分数数据。使用CIBERSORT方法将RNA测序数据转化为癌症基因组图谱-ccRCC样品的微阵列数据，其微阵列和RNA测序数据可在癌症免疫组图谱网站上获得。ccRCC患者的总生存期（OS）和无病生存期（DFS）分析显示，M1巨噬细胞（OS，P =.00000134; DFS，P =.00958）和中性粒细胞（OS，P =.00000723; DFS，P =.0255）具有显著性。 诊断时的年龄（P <0.0001，c-index = 0.59）、肿瘤分期（P <0.0001，c-index = 0.667）、分期（P <0.0001，c-index = 0.729）、肿瘤组织学分级（P <0.0001，c-index = 0.624）和血红蛋白水平（P <0.0001，c-index = 0.583）是OS的独立预测因子。同样，分期、血红蛋白水平和血清钙水平是DFS的独立预测因子。 M1巨噬细胞分数与肿瘤分期、分期和肿瘤组织学分级之间存在显著相关性。分期和肿瘤组织学分级与中性粒细胞比例相关。提示TIL与ccRCC的临床病理特征及预后相关。ccRCC患者的预后可能根据TIL分数而不同。
Renal cell carcinoma (RCC) is the leading cancer affecting humans; however, the relationship between tumour-infiltrating lymphocytes (TILs) and patient prognosis in RCC is relatively unreported. This study aimed to investigate the relationships among factors (TIL, clinicopathological characteristics, and patient prognosis in RCC). This retrospective study evaluated 533 patients with clear cell renal cell carcinoma (ccRCC) deposited in the the Cancer Genome Atlas between 2004 and 2015. We downloaded immune cell type absolute fraction data for ccRCC patients from the Cancer Immunome Atlas database. The CIBERSORT method was used to transform RNA-sequencing data into microarray data for the cancer genome atlas -ccRCC samples for which microarray and RNA-sequencing data were available on the the Cancer Immunome Atlas website. The overall survival (OS) and disease free survival (DFS) analyses of ccRCC patients showed that M1 macrophages (OS, P = .00000134; DFS, P = .00958) and neutrophils (OS, P = .00000723; DFS, P = .0255) were significant. Age at diagnosis (P < .0001, c-index = 0.59), tumour stage (P < .0001, c-index = 0.667), stage (P < .0001, c-index = 0.729), neoplasm histological grade (P < .0001, c-index = 0.624), and haemoglobin level (P < .0001, c-index = 0.583) were independent predictors of OS. Similarly, the stage, haemoglobin level, and serum calcium level were independent predictors of DFS. There were significant correlations between the M1 macrophage fraction and tumour stage, stage, and neoplasm histological grade. Stage and neoplasm histological grade showed associations with the neutrophil fraction. The correlations between TILs and prognosis and clinicopathological characteristics in ccRCC were demonstrated. The prognosis of ccRCC patients may differ according to the TIL fractions.