Cancer survivorship issues with radiation and hemorrhagic cystitis in gynecological malignancies.
Cancer survivorship issues with radiation and hemorrhagic cystitis in gynecological malignancies.
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妇科恶性肿瘤中辐射和出血性膀胱炎的癌症生存问题。
DOI：
10.1007/s11255-018-1970-2
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发表时间：
2018-10
影响因子：
2
通讯作者：
Klaudia SW
中科院分区：
文献类型：
--
作者：
Zwaans BMM;Lamb LE;Bartolone S;Nicolai HE;Chancellor MB;Klaudia SW
鉴于越来越多的癌症被更早地诊断出来，癌症的治疗也在改善，癌症幸存者的健康问题变得越来越普遍和明显。用于治疗妇科癌症的盆腔放射治疗可导致对膀胱的长期附带损伤，这种情况称为放射性膀胱炎（RC）。晚期后遗症可能需要多年的发展，包括尿失禁和疼痛以及血尿。RC是一种罕见但可能危及生命的疾病，几乎没有管理和治疗选择。关于妇科癌症治疗后放射对膀胱的影响，文献中的数据有限，我们在此对妇科盆腔放射的癌症生存率问题文献进行综述。放射性出血性膀胱炎患者有治疗选择。然而，大多数治疗都有风险或仅在短时间内有效，目前没有治疗方法可以逆转疾病进展。此外，没有任何标准化的准则来说明首选的管理办法。常见的治疗包括高压氧治疗、凝块排出、电灼、膀胱内滴注收敛剂和手术。新的开发策略包括肉毒杆菌毒素注射和脂质体-他克莫司滴注。这些治疗和策略进行了讨论。在这篇综述中，我们将介绍RC的当前和先进的治疗策略，以帮助癌症幸存者处理长期的膀胱健康问题。
Given that more cancers are being diagnosed earlier and that treatment of cancer is improving, health issues of cancer survivors are becoming more common and apparent. Pelvic radiation therapy for the treatment of gynecological cancers can lead to long-term collateral damage to the bladder, a condition termed radiation cystitis (RC). Late sequelae may take many years to develop and include incontinence and pain as well as hematuria. RC is a rare but potentially life-threatening condition for which there are few management and treatment options. There are limited data in the literature regarding the effects of radiation on the bladder after gynecological cancer therapy and we hereby review the literature on cancer survivorship issues of pelvic radiation for gynecology literature. Treatment options are available for patients with radiation-induced hemorrhagic cystitis. However, most treatments are risky or only effective for a short timeframe and no therapy is currently available to reverse the disease progress. Furthermore, no standardized guidelines exist describing preferred management options. Common therapies include hyperbaric oxygen therapy, clot evacuation, fulguration, intravesical instillation of astringent agents, and surgery. Novel developing strategies include Botulinum Toxin injections and liposomal-tacrolimus instillations. These treatments and strategies are discussed. In this review, we will present current and advanced therapeutic strategies for RC to help cancer survivors deal with long-term bladder health issues.
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影响因子：
6.6
作者：
Fazili, Tajammul;Bhat, Tahir R.;Mufti, G. R.
通讯作者：
Mufti, G. R.
影响因子：
5.7
作者：
CHASSAGNE, D;SISMONDI, P;MICHEL, G
通讯作者：
MICHEL, G
影响因子：
23.4
作者：
Chuang, Yao-Chi;Yoshimura, Naoki;Chancellor, Michael B.
通讯作者：
Chancellor, Michael B.
影响因子：
1.2
作者：
Isono-Nakata R;Tsubamoto H;Ueda T;Inoue K;Shibahara H
通讯作者：
Shibahara H
影响因子：
4.7
作者：
LEVENBACK, C;EIFEL, PJ;GERSHENSON, DM
通讯作者：
GERSHENSON, DM