THE CUMULATIVE DOSE-RESPONSE EFFECT OF EICOSAPENTAENOIC AND DOCOSAHEXAENOIC ACID ON BLOOD-PRESSURE, PLASMA-LIPID PROFILE AND DIET PATTERN IN MILD TO MODERATE ESSENTIAL HYPERTENSIVE BLACK PATIENTS
THE CUMULATIVE DOSE-RESPONSE EFFECT OF EICOSAPENTAENOIC AND DOCOSAHEXAENOIC ACID ON BLOOD-PRESSURE, PLASMA-LIPID PROFILE AND DIET PATTERN IN MILD TO MODERATE ESSENTIAL HYPERTENSIVE BLACK PATIENTS
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DOI：
10.1016/0952-3278(92)90043-i
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发表时间：
1992-08-01
影响因子：
3
通讯作者：
SMITH, KA
中科院分区：
文献类型：
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作者：
DUPLOOY, WJ;VENTER, CP;SMITH, KA
本研究采用二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)的累积给药方式，每6周给药一次，从10 mg开始，然后每天给轻、中度高血压黑人患者100 mg、1000 mg和10000 mg EPA。相应的DHA剂量分别为3、33、333和3333 mg。对照组在整个24周内都服用橄榄油作为安慰剂。24周后，安慰剂组的舒张压和收缩压低于EPA和DHA组。在试验的任何阶段，都没有看到对血浆甘油三酯、胆固醇、高密度脂蛋白-胆固醇和伽马-谷氨酰转肽酶的影响。在EPA组，血浆游离EPA从1000 mg开始显着升高，而血浆游离花生四烯酸(AA)在1000 mg EPA后显著降低。在试验期间，其他血浆游离必需脂肪酸没有变化，尽管高密度脂蛋白：胆固醇略有增加，但随着EPA和DHA的增加并不显著。没有观察到饮食模式或体重的显著变化。因此，除了降低血浆AA外，补充EPA和DHA对轻中度高血压黑人患者没有任何有益的影响。
In this study eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were given in a cumulative manner, every 6 weeks, starting with 10 mg, then 100 mg, 1000 mg and 10 000 mg EPA daily to mild to moderate essential hypertensive black patients. The corresponding DHA doses were 3, 33, 333 and 3333 mg. A control group was given olive oil as placebo for the entire 24 weeks. The placebo group had lower diastolic and systolic blood pressures after 24 weeks than the EPA and DHA group. No effect was seen on plasma triglycerides, cholesterol, HDL-cholesterol and gamma-glutamyltranspeptidase at any stage of the trial. In the EPA group plasma free-EPA increased significantly from 1000 mg onwards and plasma free-arachidonic acid (AA) decreased after 1000 mg EPA. No other plasma free essential fatty acid changed during the trial, although the HDL:cholesterol increased slightly but non-significantly with an increase in EPA and DHA. No significant changes in diet pattern or body mass was observed. It is therefore concluded that EPA and DHA supplementation had no beneficial effects in mild to moderate essential hypertensive black patients except for a lowering of plasma AA.