Microvessel density in invasive breast cancer assessed by dynamic Gd-DTPA enhanced MRI
Microvessel density in invasive breast cancer assessed by dynamic Gd-DTPA enhanced MRI
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DOI：
10.1002/jmri.1880070302
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发表时间：
1997-05-01
期刊：
影响因子：
--
通讯作者：
Horsman, A
中科院分区：
文献类型：
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作者：
Buckley, DL;Drew, PJ;Horsman, A
据推测，施用造影剂后乳腺癌所表现出的快速增强是肿瘤血管生成的直接结果。然而，迄今为止，几乎没有发布定量数据来支持这一观点。一项回顾性研究比较了从 40 名患者获得的动态对比增强数据，并在用因子 vm 相关抗原免疫组织化学染色的标本中评估了微血管密度 (MVD)。使用简单的增强指数和二室动力学模型对动态数据进行了定量分析。初始增强和 MVD 之间存在中等但显着的相关性，并且当单独考虑淋巴结阳性肿瘤时，这种相关性得到加强（r = .77，P
It has been postulated that the rapid enhancement demonstrated by breast carcinomas after administration of contrast media is a direct result of tumor angiogenesis. However, to date, little quantitative data have been published to support this view. A retrospective study has been undertaken to compare dynamic contrast-enhanced data obtained from 40 patients with microvessel density (MVD) evaluated in specimens immunohistochemically stained with a factor vm related antigen, The dynamic data were analyzed quantitatively using both simple indices of enhancement and a two-compartment kinetic model. A moderate but significant correlation was demonstrated between initial enhancement and MVD, and this correlation strengthened when node-positive tumors were considered in isolation (r =.77, P