MR Angiography of Renal Transplant Vasculature with Ferumoxytol: Comparison of High-Resolution Steady-State and First-Pass Acquisitions
MR Angiography of Renal Transplant Vasculature with Ferumoxytol: Comparison of High-Resolution Steady-State and First-Pass Acquisitions
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DOI：
10.1016/j.acra.2015.10.021
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发表时间：
2016-03-01
影响因子：
4.8
通讯作者：
Chaudhari, Abhijit J.
中科院分区：
文献类型：
--
作者：
Corwin, Michael T.;Fananapazir, Ghaneh;Chaudhari, Abhijit J.
基本原理和目的：本研究旨在量化肾移植受者使用阿魏酸的稳态和首次通过磁共振血管成像(MRA)在信噪比(SNR)和血管锐度方面的差异。材料和方法：我们对接受稳态和首次通过MRA的成年患者进行了回顾性研究，以评估肾移植的血管系统。计算髂外动脉的SNR，并计算两次采集的髂外动脉和肾移植动脉的血管锐度。结果：共纳入15例患者(平均年龄56.9岁，男性10例)。首次通过MRA的髂外动脉平均信噪比为42.2(SD，11.9)，稳态MRA为41.8(SD，9.7)(p=0.92)。对于髂外动脉(1.24比0.80 mm(-1)，p<；0.01)和肾移植动脉(1.26比0.79 mm(-1)，p<；0.01)，稳态MRA的平均血管锐度显著高于首过MRA(1.24比0.80 mm(-1)，p<；0.01)。结论：与传统的首过MRA相比，在肾移植患者中，使用阿魏缩醇的稳态MRA改善了血管的锐度，同时保持了同等的信噪比。
Rationale and Objectives: This work aimed to quantify the differences in signal-to-noise ratio (SNR) and vessel sharpness between steady-state and first-pass magnetic resonance angiography (MRA) with ferumoxytol in renal transplant recipients.Materials and Methods: We performed a retrospective study of adult patients who underwent steady-state and first-pass MRA with ferumoxytol to evaluate renal transplant vasculature. SNR was calculated in the external iliac artery, and vessel sharpness was calculated in the external iliac and renal transplant arteries for both acquisitions. Data were compared using Student's t test.Results: Fifteen patients were included (mean age 56.9 years, 10 males). The mean SNR of the external iliac artery was 42.2 (SD, 11.9) for the first-pass MRA and 41.8 (SD, 9.7) for the steady-state MRA (p = 0.92). The mean vessel sharpness was significantly higher for the steady-state MRA compared to first-pass MRA for both external iliac (1.24 vs. 0.80 mm(-1), p < 0.01) and renal transplant arteries (1.26 vs. 0.79 mm(-1), p < 0.01).Conclusion: Steady-state MRA using ferumoxytol improves vessel sharpness while maintaining equivalent SNR compared to conventional first-pass MRA in renal transplant patients.