Pyrogenic Specificity of Streptococcal Exotoxins, Staphylococcal Enterotoxin, and Gram-Negative Endotoxin
Pyrogenic Specificity of Streptococcal Exotoxins, Staphylococcal Enterotoxin, and Gram-Negative Endotoxin
复制标题
链球菌外毒素、葡萄球菌肠毒素和革兰氏阴性内毒素的热原特异性
作者：
K. Brunson;D. W. Watson
链球菌外毒素和葡萄球菌肠毒素具有共同的生物学特性，包括致热性、淋巴细胞有丝分裂原性和增强革兰氏阴性内毒素的致死性。这些毒素的类比促进了比较热源研究。当美国荷兰兔通过反复静脉注射少量葡萄球菌肠毒素进行免疫时，与以前没有注射过的对照动物相比，它们在攻击时表现出较低的发热反应。相同的动物在用链球菌外毒素A、B或C攻击时的反应与对照组相似，在相互交叉试验中没有观察到交叉反应，使用对链球菌毒素免疫的动物和用葡萄球菌肠毒素攻击的动物。没有观察到链球菌或葡萄球菌毒素与细菌内毒素之间的交叉反应。
Streptococcal exotoxin and staphylococcal enterotoxin share several biological properties, including pyrogenicity, lymphocyte mitogenicity, and enhancement of gram-negative endotoxin lethality. These analogies of the toxins prompted comparative pyrogenic studies. When American Dutch rabbits were immunized by repeated intravenous injections of small amounts of staphylococcal enterotoxin, they exhibited a decreased febrile response upon challenge when compared with control animals not previously injected. The same animals responded similarly to control groups when challenged with streptococcal exotoxin A, B, or C. No cross-reactivity was observed in reciprocal cross-tests, using animals immune to the streptococcal toxins and challenging with staphylococcal enterotoxin. No cross-reactivity between either the streptococcal or staphylococcal toxins and bacterial endotoxin was observed.