MicroRNA-9 regulates neural progenitor proliferation and differentiation in both pallium and subpallium by targeting Foxg1, Nr2e1, Gsh2 and Meis2
MicroRNA-9 regulates neural progenitor proliferation and differentiation in both pallium and subpallium by targeting Foxg1, Nr2e1, Gsh2 and Meis2
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DOI：
10.1016/j.ydbio.2010.05.440
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发表时间：
2010-08
影响因子：
2.7
通讯作者：
M. Shibata;Hiromi Nakao;H. Kiyonari;T. Abe;S. Aizawa
中科院分区：
文献类型：
--
作者：
M. Shibata;Hiromi Nakao;H. Kiyonari;T. Abe;S. Aizawa
随后，microRNA-9增强Nr2e1和Pax6的表达，以促进脑室和脑室下区的祖细胞增殖。MicroRNA-9靶向Nr2e1mRNA，协同Eavl1和MSIL增强其蛋白表达，并抑制Meis2的表达，从而抑制Pax6的表达。伴随而来的是，在双突变体中，每一层皮质减少，中间神经元向大脑皮层的切向迁移受到损害。在大脑皮层下，microRNA-9通过抑制Gsh2和FOXG1的表达来负向控制前体细胞的增殖以产生纹状体神经元；microRNA-9还通过调节Pax6、Nr2e1和Gsh2的表达来调节大脑皮质/丘脑下缘和大脑皮层腹侧的形成。此外，在这两个突变体中，苍白球缺失，走廊畸形，丘脑皮质轴突和皮质轴突错位。DOI：10.1016/J.伊迪比奥。2010.05。四百四十
Subsequently, microRNA-9 enhances Nr2e1 and Pax6 expressions to promote progenitor proliferation in the ventricular and subventricular zones. MicroRNA-9 targets Nr2e1 mRNA to enhance its protein expression in cooperation with Elavl1 and Msil, and it suppresses the expression of Meis2 that inhibits Pax6 expression. Concomitantly, each cortical layer is reduced and the tangential migration of interneurons into the pallium is impaired in the double mutants. In the subpallium, microRNA-9 suppresses Gsh2 and Foxg1 expression to negatively control progenitor proliferation for the production of the striatum neurons; microRNA-9 also regulates the formation of the pallial/subpallial boundary and ventral pallium through its regulation of Pax6, Nr2e1 and Gsh2 expressions. Furthermore, the globus pallidus is missing, the corridor is malformed and thalamocortical axons and corticofugal axons are miss-routed in the double mutants. doi: 10.1016/j. ydbio. 2010.05. 440