Integration of phytochemicals and phytotherapy into cancer precision medicine.
Integration of phytochemicals and phytotherapy into cancer precision medicine.
复制标题
将植物化学物质和植物疗法整合到癌症精确医学中。
DOI：
10.18632/oncotarget.17466
复制
发表时间：
2017-07-25
期刊：
影响因子：
--
通讯作者：
Daak S
中科院分区：
文献类型：
--
作者：
Efferth T;Saeed MEM;Mirghani E;Alim A;Yassin Z;Saeed E;Khalid HE;Daak S
在20世纪70年代和80年代，个体化治疗的概念试图在没有达到临床常规的情况下，发展个体药物反应性的预测性体外试验。精准医学试图设计新的个体癌症治疗策略。利用生物信息学，从海量数据中提取相关知识。然而，由于遗传和表型上不同的细胞亚群，肿瘤的异质性给化疗带来了挑战，这可能导致难治性肿瘤。天然产物一直是癌症治疗的重要资源（如长春花生物碱、喜树碱、紫杉醇等），也是新药的来源。针对肿瘤相关蛋白开发的靶向药物是精准医学的基础。植物天然产物是靶向治疗的重要资源。植物化学物质和草药混合物起多特异性作用，即它们同时攻击多个目标。网络药理学有助于识别药物基因组网络的复杂性和肿瘤中扭曲的新信号网络。在本文中，我们从概念上概述了如何将植物化学物质和植物疗法结合到西医学中来解决耐药性问题。现代技术平台（如“组学”技术、DNA/RNA测序和网络药理学）可以应用于多种治疗方式，如细胞毒性和靶向化疗，以及植物化学物质和植物疗法。因此，这些技术代表了融合临床肿瘤学和传统医学这两个世界最好的整合势头。综上所述，将植物化学物质和植物疗法整合到癌症精准医疗中是化学合成化学品和治疗性抗体的宝贵资产。
Concepts of individualized therapy in the 1970s and 1980s attempted to develop predictive in vitro tests for individual drug responsiveness without reaching clinical routine. Precision medicine attempts to device novel individual cancer therapy strategies. Using bioinformatics, relevant knowledge is extracted from huge data amounts. However, tumor heterogeneity challenges chemotherapy due to genetically and phenotypically different cell subpopulations, which may lead to refractory tumors. Natural products always served as vital resources for cancer therapy (e.g., Vinca alkaloids, camptothecin, paclitaxel, etc.) and are also sources for novel drugs. Targeted drugs developed to specifically address tumor-related proteins represent the basis of precision medicine. Natural products from plants represent excellent resource for targeted therapies. Phytochemicals and herbal mixtures act multi-specifically, i.e. they attack multiple targets at the same time. Network pharmacology facilitates the identification of the complexity of pharmacogenomic networks and new signaling networks that are distorted in tumors. In the present review, we give a conceptual overview, how the problem of drug resistance may be approached by integrating phytochemicals and phytotherapy into academic western medicine. Modern technology platforms (e.g. “-omics” technologies, DNA/RNA sequencing, and network pharmacology) can be applied for diverse treatment modalities such as cytotoxic and targeted chemotherapy as well as phytochemicals and phytotherapy. Thereby, these technologies represent an integrative momentum to merge the best of two worlds: clinical oncology and traditional medicine. In conclusion, the integration of phytochemicals and phytotherapy into cancer precision medicine represents a valuable asset to chemically synthesized chemicals and therapeutic antibodies.
登录
查看更多内容
影响因子：
3.7
作者：
Cerami E;Demir E;Schultz N;Taylor BS;Sander C
通讯作者：
Sander C
影响因子：
6.4
作者：
Chakravarti, Nitin;Myers, Jeffrey N.;Aggarwal, Bharat B.
通讯作者：
Aggarwal, Bharat B.
影响因子：
5.7
作者：
Azmi AS;Wang Z;Philip PA;Mohammad RM;Sarkar FH
通讯作者：
Sarkar FH
影响因子：
2.3
作者：
Efferth, T;Miyachi, H;Gebhart, E
通讯作者：
Gebhart, E
影响因子：
7.9
作者：
Derosa, Giuseppe;Romano, Davide;Maffioli, Pamela
通讯作者：
Maffioli, Pamela