Early netrin‐1 expression impairs central nervous system remyelination
Early netrin‐1 expression impairs central nervous system remyelination
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DOI：
10.1002/ana.24201
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发表时间：
2014-08
影响因子：
11.2
通讯作者：
V. Tepavčević;C. Kerninon;M. Aigrot;E. Meppiel;Sabah Mozafari;Raphaelle Arnould-Laurent;P. Ravassard;T. Kennedy;B. Nait-Oumesmar;C. Lubetzki
中科院分区：
文献类型：
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作者：
V. Tepavčević;C. Kerninon;M. Aigrot;E. Meppiel;Sabah Mozafari;Raphaelle Arnould-Laurent;P. Ravassard;T. Kennedy;B. Nait-Oumesmar;C. Lubetzki
慢性脱髓鞘多发性硬化（MS）病变的特点往往是稀缺的未分化的少突胶质祖细胞（OPC），这表明耗尽了当地的OPC池，然后失败的招聘和分化。脱髓鞘后刺激OPC的迅速募集可以通过在修复许可期提供足够数量的髓鞘再生细胞来改善髓鞘修复。了解决定这一过程的机制可能具有重要的治疗意义。因此，我们研究了导向分子netrin-1在OPC募集和中枢神经系统（CNS）髓鞘再生中的作用。
Chronically demyelinated multiple sclerosis (MS) lesions are frequently characterized by scarce undifferentiated oligodendrocyte progenitor cells (OPCs), suggesting the exhaustion of a local OPC pool followed by failure of recruitment and differentiation. Stimulating prompt OPC recruitment following demyelination could improve myelin repair by providing sufficient numbers of remyelinating cells during the repair‐permissive period. Understanding mechanisms that determine this process may have important therapeutic implications. We therefore investigated the role of the guidance molecule netrin‐1 in OPC recruitment and central nervous system (CNS) remyelination.