CHROMOSOMAL LOCALIZATION OF MOUSE AND HUMAN NEUROTENSIN RECEPTOR GENES
CHROMOSOMAL LOCALIZATION OF MOUSE AND HUMAN NEUROTENSIN RECEPTOR GENES
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DOI：
10.1007/bf00389545
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发表时间：
1994-05-01
期刊：
影响因子：
2.5
通讯作者：
ROSTENE, W
中科院分区：
文献类型：
--
作者：
LAURENT, P;CLERC, P;ROSTENE, W
神经降压素是一种十三肽，在中枢神经系统和外周神经系统中发挥多种神经递质或神经调节作用。这些作用由高亲和力受体（Ntsr）介导。编码高亲和力受体的大鼠和人类cDNA最近都已被克隆。Ntsr探针的可用性使我们能够在小鼠和人类染色体上定位相应的基因。目前的数据表明，Ntsr基因被分配到小鼠染色体（Chr）2的H区和人类Chr 20的长臂。
Neurotensin is a tridecapeptide that plays several neurotransmitter or neuromodulatory roles both in the central nervous system and in the periphery. These actions are mediated by a high-affinity receptor (Ntsr). Both rat and human cDNAs encoding high-affinity receptors have been recently cloned. The availability of Ntsr probes allowed us to localize the corresponding genes on the mouse and human chromosomes. The present data demonstrate that the Ntsr gene is assigned to the H region of the mouse Chromosome (Chr) 2 and to the long arm of the human Chr 20.