Characterization of BshA, bacillithiol glycosyltransferase from Staphylococcus aureus and Bacillus subtilis.
Characterization of BshA, bacillithiol glycosyltransferase from Staphylococcus aureus and Bacillus subtilis.
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DOI:
10.1016/j.febslet.2012.02.028
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发表时间:
2012-04-05
期刊:
影响因子:
3.5
通讯作者:
Rawat M
中科院分区:
文献类型:
--
作者:
Upton H;Newton GL;Gushiken M;Lo K;Holden D;Fahey RC;Rawat M
The first step during bacillithiol (BSH) biosynthesis involves the formation of N-acetylglucosaminylmalate from UDP-N-acetylglucosamine and L-malate and is catalyzed by a GT4 class glycosyltransferase enzyme (BshA). Recombinant Staphylococcus aureus and Bacillus subtilis BshA were highly specific and active with L-malate but the former showed low activity with D-glyceric acid and the latter with D-malate. We show that BshA is inhibited by BSH and similarly that MshA (first enzyme of mycothiol biosynthesis) is inhibited by the final product MSH.
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DOI:
10.1016/0304-4165(75)90205-6
发表时间:
1975-01-01
期刊:
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子:
--
作者:
APONTOWEIL, P;BERENDS, W
通讯作者:
BERENDS, W
影响因子:
4.8
作者:
Vetting, Matthew W.;Frantom, Patrick A.;Blanchard, John S.
通讯作者:
Blanchard, John S.
影响因子:
2.9
作者:
Parsonage D;Newton GL;Holder RC;Wallace BD;Paige C;Hamilton CJ;Dos Santos PC;Redinbo MR;Reid SD;Claiborne A
通讯作者:
Claiborne A
影响因子:
14.8
作者:
Newton, Gerald L.;Rawat, Mamta;La Clair, James J.;Jothivasan, Vishnu Karthik;Budiarto, Tanya;Hamilton, Chris J.;Claiborne, Al;Helmann, John D.;Fahey, Robert C.
通讯作者:
Fahey, Robert C.
影响因子:
2.9
作者:
Ruane, Karen M.;Davies, Gideon J.;Martinez-Fleites, Carlos
通讯作者:
Martinez-Fleites, Carlos