Does diabetes mellitus influence the efficacy of FDG-PET in the diagnosis of cervical cancer?
Does diabetes mellitus influence the efficacy of FDG-PET in the diagnosis of cervical cancer?
复制标题
糖尿病是否影响FDG-PET诊断宫颈癌的效果？
DOI：
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发表时间：
2005
影响因子：
9.1
通讯作者：
H. Chou
中科院分区：
文献类型：
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作者：
Yu;T. Yen;K. Ng;L. See;Chyong;T. Chang;C. Tsai;Ji;S. Hsueh;H. Chou
目的与计算机体层摄影(CT)和磁共振成像(MRI)相比，正电子发射体层摄影术(PET)在评价宫颈癌原发和复发方面可能具有更大的价值。然而，肿瘤摄取18F-2-氟-2-脱氧-d-葡萄糖(FDG)的程度有时会受到糖尿病(DM)的影响。因此，我们进行了这项前瞻性研究，以比较FDG-PET在宫颈癌合并DM和非DM患者中的诊断能力。方法选择未经治疗的晚期初发或临床可治愈复发宫颈癌患者。FDG-PET和MRI/CT扫描均在2周内完成。将患者分为以下三组：高血糖DM(空腹血糖和GT；126 mg/dl)、正常血糖DM和非DM组。病变均经组织学或临床随访证实。结果2001年2月至2003年1月，219例宫颈癌患者(初发宫颈癌75例，复发宫颈癌144例)进入分析。高血糖糖尿病组16例，正常血糖糖尿病组12例，非糖尿病组191例。高血糖糖尿病组、正常血糖糖尿病组和非糖尿病组的正电子发射计算机断层扫描在诊断转移灶(AuC，0.967/0.947/0.925，P>；0.05)或原发肿瘤/局部复发(AuC，0.950/0.938/0.979，P>；0.05)方面没有显著差异。考虑到所有DM患者，正电子发射计算机断层扫描对转移灶的检出能力显著高于核磁共振/CT扫描(AUC=0.956比0.824，P=0.012)。结论与非糖尿病患者相比，正电子发射计算机断层扫描对宫颈癌合并轻、中度糖尿病患者的诊断准确度无明显降低。
PurposeCompared with computed tomography (CT) and magnetic resonance imaging (MRI), positron emission tomography (PET) may have additional value in the assessment of primary and recurrent cervical cancer. However, the degree of tumour uptake of 18F-2-fluoro-2-deoxy-d-glucose (FDG) uptake is sometimes influenced by diabetes mellitus (DM). Therefore, we conducted this prospective study to compare the diagnostic ability of FDG-PET in patients with cervical cancer complicated by DM and those without DM.MethodsPatients with untreated locally advanced primary or clinically curable recurrent cervical carcinoma were enrolled. Both FDG-PET and MRI/CT scans were performed within 2 weeks. Patients were categorised into the following groups: hyperglycaemic DM (fasting blood sugar >126 mg/dl), euglycaemic DM and non-DM. The lesions were confirmed histologically or by clinical follow-up. The receiver operating characteristic curve method, with calculation of the area under the curve (AUC), was used to evaluate the discriminative power.ResultsFrom February 2001 to January 2003, 219 patients (75 with primary and 144 with recurrent cervical cancer) were eligible for analysis. Sixteen had hyperglycaemic DM, 12 had euglycaemic DM and 191 were in the non-DM group. The diagnostic power of PET in the hyperglycaemic DM, euglycaemic DM and non-DM groups did not differ significantly with regard to the identification of either metastatic lesions (AUC, 0.967/0.947/0.925, P>0.05) or primary tumours/local recurrence (AUC, 0.950/0.938/0.979, P>0.05). Considering all DM patients, PET showed a significantly higher detection power than MRI/CT scans in respect of metastatic lesions (AUC=0.956 vs 0.824, P=0.012).ConclusionIn comparison with its accuracy in non-DM patients, the accuracy of PET in cervical cancer patients with mild to moderate DM was not significantly reduced.
高血糖对体外肿瘤摄取氚化FDG、胸苷、L-蛋氨酸和L-亮氨酸的影响。
DOI：
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发表时间：
1997
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
影响因子：
--
作者：
Torizuka,T;Clavo,AC;Wahl,RL
通讯作者：
Wahl,RL