Targeting intracellular targets
Targeting intracellular targets
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DOI：
10.2174/1567201043334768
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发表时间：
2004-07-04
影响因子：
2.4
通讯作者：
Labhasetwar, Vinod
中科院分区：
文献类型：
--
作者：
Panyam, Jayanth;Labhasetwar, Vinod
许多治疗剂以细胞内区室作为其作用位点。将这些药物靶向递送至特定的细胞内靶点可以提高治疗效果并降低毒性。各种载体已被证明可用于不同类别治疗剂的靶向递送。在这些载体中，由生物相容性聚合物聚（D，L-丙交酯-乙交酯）（PLGA）和聚丙交酯（PLA）配制的可生物降解纳米颗粒已显示出持续细胞内递送不同治疗剂的潜力。在这篇综述中，我们讨论了不同的细胞内靶点、细胞内递送的障碍、细胞内递送的机制和途径，以及已研究的细胞内药物递送的各种载体和方法。
Many therapeutic agents have intracellular compartments as their site of action. Targeted delivery of these agents to their specific intracellular targets could result in enhanced therapeutic efficacy and reduced toxicity. Various carriers have been shown useful in targeted delivery of different classes of therapeutic agents. Among these carriers, biodegradable nanoparticles formulated from biocompatible polymers poly(D,L-lactide-co-glycolide) (PLGA) and polylactide (PLA) have shown the potential for sustained intracellular delivery of different therapeutic agents. In this review, we discuss different intracellular targets, barriers to intracellular delivery, mechanism and pathways of intracellular delivery, and various carriers and approaches that have been investigated for intracellular drug delivery.