Increasing Creatine Kinase Concentrations at the 161-km Western States Endurance Run
Increasing Creatine Kinase Concentrations at the 161-km Western States Endurance Run
复制标题
DOI：
10.1016/j.wem.2011.11.001
复制
发表时间：
2012-03-01
影响因子：
1.4
通讯作者：
Stuempfle, Kristin J.
中科院分区：
文献类型：
--
作者：
Hoffman, Martin D.;Ingwerson, Julie L.;Stuempfle, Kristin J.
客观。-在最近的161公里西部耐力跑（WSER）的完成者中观察到非常高的血肌酸激酶（CK）浓度，并建议横纹肌溶解症和低钠血症之间存在联系。因此，本研究的目的是比较CK浓度的完成者在2010年WSER与过去的值，并确定是否有血液CK和钠浓度之间的关联。2010年世界游泳锦标赛结束时，参赛者提供了血样，用于测定血液CK和钠浓度。完成时间，年龄和性别是从官方比赛结果中获得的，跑步经验是从我们的数据库中确定的，作为之前161公里超级马拉松的完成次数。在328只育肥猪中，216只（66%）的CK浓度中位数和平均值分别为20 850 IU/L和32 956 IU/L（范围为1500-264 300 IU/L），13只（6%）的值大于100 000 IU/L。这些数值在统计学上高于（P < .0001）1995年WSER报告的数值。CK浓度与完成时间、年龄、性别或跑步经验无显著相关性。从159名跑步者的亚组中获得血钠浓度，血CK和钠浓度之间的关系没有达到统计学显著性（P = 0.06，r = -0.12）。肌酸激酶浓度的2010年WSER完成高于以前报道的值。更多的研究应该集中在解释这一观察结果，并在较高的CK浓度和低钠血症之间是否有可能的联系。
Objective.-Very high blood creatine kinase (CK) concentrations have been observed among recent finishers of the 161-km Western States Endurance Run (WSER), and it has been suggested that there is a link between rhabdomyolysis and hyponatremia. Therefore, the purpose of this study was to compare CK concentrations of finishers in the 2010 WSER with past values, and to determine whether there was an association between blood CK and sodium concentrations.Methods.-Consenting 2010 WSER finishers provided blood samples at the finish for determination of blood CK and sodium concentrations. Finish time, age, and gender were obtained from official race results, and running experience was determined from our database as number of prior 161-km ultramarathon finishes.Results.-From 216(66%) of the 328 finishers, median and mean CK concentrations were found to be 20 850 IU/L and 32 956 IU/L, respectively (range 1500-264 300 IU/L), and 13 (6%) had values greater than 100 000 IU/L. These values were statistically higher (P < .0001) than those reported from the 1995 WSER. The CK concentration was not significantly associated with finish time, age, gender, or running experience. Blood sodium concentrations were obtained from a subgroup of 159 runners, and the relationship between blood CK and sodium concentrations did not reach statistical significance (P = .06, r = -0.12).Conclusions.-Creatine kinase concentrations of 2010 WSER finishers are higher than values previously reported. More research should focus on explaining this observation and on whether there is a possible link between higher CK concentrations and hyponatremia.