A Comparison of Two Objective Measures of Binaural Processing: The Interaural Phase Modulation Following Response and the Binaural Interaction Component.
A Comparison of Two Objective Measures of Binaural Processing: The Interaural Phase Modulation Following Response and the Binaural Interaction Component.
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DOI：
10.1177/2331216515619039
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发表时间：
2015-12-30
影响因子：
2.7
通讯作者：
McAlpine D
中科院分区：
文献类型：
--
作者：
Haywood NR;Undurraga JA;Marquardt T;McAlpine D
双耳处理的临床客观测量一直受到关注。一种通常提出的测量是双耳交互分量（BIC），其通常通过记录听觉脑干反应（ABR）来获得一一BIC反映双耳ABR与单耳ABR之和之间的差异（即，双耳−（左+右））。我们最近开发了一种替代的，直接测量灵敏度的耳间时间差，即，以下响应调制的耳间相位差（以下响应的耳间相位调制; IPM-FR）。为了获得这一措施，提出了一个正在进行的diotically幅度调制信号，并在调制周期中的最小值定期切换的载波的耳间相位差。这种对耳间相位差的周期性调制可以引起稳态跟随响应。使用16通道脑电图系统比较了10名听力正常受试者的BIC和IPM-FR测量结果。ABR和IPM-FR都是从相似的电极位置最清楚地观察到的-从耳朵附近的电极获得的差分记录（例如，乳突）相对于顶点电极（Cz）。尽管所有受试者均显示出清晰的ABR，但BIC未可靠观察到。相比之下，IPM-FR通常引起稳健且显著的响应。此外，IPM-FR措施需要相当短的记录会话。由于IPM-FR幅度随耳间相位差调制深度而变化，因此它可以潜在地用作感知显著性的相关性。总体而言，IPM-FR似乎是比BIC更合适的临床测量。
There has been continued interest in clinical objective measures of binaural processing. One commonly proposed measure is the binaural interaction component (BIC), which is obtained typically by recording auditory brainstem responses (ABRs)—the BIC reflects the difference between the binaural ABR and the sum of the monaural ABRs (i.e., binaural − (left + right)). We have recently developed an alternative, direct measure of sensitivity to interaural time differences, namely, a following response to modulations in interaural phase difference (the interaural phase modulation following response; IPM-FR). To obtain this measure, an ongoing diotically amplitude-modulated signal is presented, and the interaural phase difference of the carrier is switched periodically at minima in the modulation cycle. Such periodic modulations to interaural phase difference can evoke a steady state following response. BIC and IPM-FR measurements were compared from 10 normal-hearing subjects using a 16-channel electroencephalographic system. Both ABRs and IPM-FRs were observed most clearly from similar electrode locations—differential recordings taken from electrodes near the ear (e.g., mastoid) in reference to a vertex electrode (Cz). Although all subjects displayed clear ABRs, the BIC was not reliably observed. In contrast, the IPM-FR typically elicited a robust and significant response. In addition, the IPM-FR measure required a considerably shorter recording session. As the IPM-FR magnitude varied with interaural phase difference modulation depth, it could potentially serve as a correlate of perceptual salience. Overall, the IPM-FR appears a more suitable clinical measure than the BIC.