Effect of conditioned fear stress on dopamine release in the rat prefrontal cortex
Effect of conditioned fear stress on dopamine release in the rat prefrontal cortex
复制标题
条件性恐惧应激对大鼠前额皮质多巴胺释放的影响
DOI：
10.1016/0304-3940(96)12631-8
复制
发表时间：
1996
影响因子：
2.5
通讯作者：
H. Saito
中科院分区：
文献类型：
--
作者：
M. Yoshioka;M. Matsumoto;H. Togashi;H. Saito
用在体微透析法研究了条件性恐惧应激(CFS)对大鼠内侧前额叶皮质多巴胺释放的影响。CFS(暴露在先前发生过足部电击的环境中)导致明显的运动抑制，即冰冻行为。CFS可增加内侧前额叶皮质细胞外多巴胺浓度。大鼠回到笼养后，多巴胺的增加恢复到治疗前的水平。安定(0.5 mg/kg，i.p.)抑制CFS诱导的冰冻行为和内侧前额叶皮质细胞外多巴胺水平。这些发现表明，焦虑和前额叶皮质中的多巴胺释放可能有关。
The effects of conditioned fear stress (CFS) on dopamine release in the medial prefrontal cortex were studied by in vivo microdialysis in the rat. CFS (exposure to an environment in which foot-shock had been delivered previously) induced a marked suppression of motility, i.e., freezing behavior. Extracellular concentrations of dopamine in the medial prefrontal cortex were increased by CFS. The increase of dopamine returned to the pretreatment levels when rats were returned to the home cages. Diazepam (0.5 mg/kg, i.p.) suppressed both the CFS-induced freezing behavior and extracellular dopamine levels in the medial prefrontal cortex. These findings suggest that anxiety and dopamine release in the prefrontal cortex might be related.