A functional dosage compensation complex required for male killing in Drosophila
A functional dosage compensation complex required for male killing in Drosophila
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DOI：
10.1126/science.1107182
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发表时间：
2005-03-04
期刊：
影响因子：
56.9
通讯作者：
Hurst, GDD
中科院分区：
文献类型：
--
作者：
Veneti, Z;Bentley, JK;Hurst, GDD
选择性杀死雄性的细菌（“雄性杀手”）在50多年前首次在果蝇中被发现，并已被证明在昆虫中很常见。然而，致病性的性别特异性的机制仍然未知。我们测试了螺旋体poulsonii杀死携带突变基因的黑腹果蝇配偶的能力，这些突变基因编码剂量补偿复合物。这种细菌不能杀死缺少复合物中五种蛋白质成分中任何一种的配偶。
Bacteria that selectively kilt males ("male-killers") were first characterized more than 50 years ago in Drosophila and have proved to be common in insects. However, the mechanism by which sex specificity of virulence is achieved has remained unknown. We tested the ability of Spiroplasma poulsonii to kill Drosophila melanogaster mates carrying mutations in genes that encode the dosage compensation complex. The bacterium failed to kill mates lacking any of the five protein components of the complex.