Biofilms in periprosthetic orthopedic infections.
Biofilms in periprosthetic orthopedic infections.
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DOI：
10.2217/fmb.14.64
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发表时间：
2014
影响因子：
3.1
通讯作者：
Stoodley P
中科院分区：
文献类型：
--
作者：
McConoughey SJ;Howlin R;Granger JF;Manring MM;Calhoun JH;Shirtliff M;Kathju S;Stoodley P
随着全关节置换术和内固定手术的数量不断增加，术后感染的威胁具有重大的临床意义。这些感染可能会对患者产生高度病态的后果，患者往往要忍受额外的手术和长期暴露于全身抗生素，这两种方法都不能保证解决感染。特别值得关注的是细菌生物膜发展的威胁，因为生物膜介导的感染难以诊断，缺乏有效的治疗方法。开发的治疗策略具有生物膜形成的靶向机制以及这些细菌相互通信以承担特定角色（如生物膜内的持留细胞）的手段。此外，在实验室和动物研究中，通过假体的新型涂层和通过可吸收载体局部递送高浓度抗生素来预防感染已显示出前景。生物膜的发展，特别是在关节成形术的环境，以及未来的诊断和治疗方案进行了讨论。
As the number of total joint arthroplasty and internal fixation procedures continues to rise, the threat of infection following surgery has significant clinical implications. These infections may have highly morbid consequences to patients, who often endure additional surgeries and lengthy exposures to systemic antibiotics, neither of which are guaranteed to resolve the infection. Of particular concern is the threat of bacterial biofilm development, since biofilm-mediated infections are difficult to diagnose and effective treatments are lacking. Developing therapeutic strategies have targeted mechanisms of biofilm formation and the means by which these bacteria communicate with each other to take on specialized roles such as persister cells within the biofilm. In addition, prevention of infection through novel coatings for prostheses and the local delivery of high concentrations of antibiotics by absorbable carriers has shown promise in laboratory and animal studies. Biofilm development, especially in an arthoplasty environment, and future diagnostic and treatment options are discussed.