Design and synthesis of chiral hybrid spiro (isoxazole-isoxazoline) ligands
Design and synthesis of chiral hybrid spiro (isoxazole-isoxazoline) ligands
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DOI：
10.1016/j.tetasy.2007.04.010
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发表时间：
2007-05-16
影响因子：
--
通讯作者：
Sasai, Hiroaki
中科院分区：
文献类型：
--
作者：
Koranne, Priti S.;Tsujihara, Tetsuya;Sasai, Hiroaki
以异恶唑和异恶唑啉为配位单元，合成了一种新型的含不对称螺[4.5]癸烷骨架的手性杂化配体。发现这些配体的Pd络合物有效地活化烯烃朝向二烯基醇的对映选择性串联环化，提供高达97%ee的环化产物。（c）2007 Elsevier Ltd.保留所有权利。
Novel chiral hybrid ligands containing an unsymmetrical spiro[4.5]decane skeleton with isoxazole and isoxazoline as the two coordinating units have been synthesized. Pd complexes of these ligands were found to be effective in activating olefins towards enantioselective tandem cyclization of a dialkenyl alcohol, providing the cyclized products in up to 97% ee. (c) 2007 Elsevier Ltd. All rights reserved.