Light Deprivation Induces Depression-Like Behavior and Suppresses Neurogenesis in Diurnal Mongolian Gerbil (Meriones unguiculatus)
Light Deprivation Induces Depression-Like Behavior and Suppresses Neurogenesis in Diurnal Mongolian Gerbil (Meriones unguiculatus)
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光照剥夺会诱发日间蒙古沙鼠（Meriones unguiculatus）的抑郁样行为并抑制神经发生
DOI：
10.3727/096368910x539065
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发表时间：
2011-01-01
影响因子：
3.3
通讯作者：
So, Kwok-Fai
中科院分区：
文献类型：
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作者：
Lau, Benson Wui-Man;Ren, Chaoran;So, Kwok-Fai
最近的证据表明，成人神经发生有助于不同的精神疾病，包括抑郁症，焦虑症和精神分裂症的病理生理。季节性情感障碍（SAD）是一种特定形式的复发性抑郁症，可由缩短的光照时间引起。目前尚不清楚神经发生是否在SAD或改变光/暗周期下受到影响。本研究的目的是研究蒙古沙鼠，主要是白天活动的啮齿动物，在光剥夺下，是否影响神经发生和树突状细胞的未成熟神经元生长。将动物分为对照组（12 h光照：12 h黑暗）和光剥夺组（24 h黑暗）。2周后评估抑郁样行为和神经发生。与对照组相比，光剥夺组沙土鼠在悬尾实验和强迫游泳实验中不动时间增加，提示抑郁样行为的诱导。光剥夺组海马和室管膜下区的细胞增殖明显减少，神经元分化也减少。通过双皮质素染色和Sholl分析，光剥夺抑制了未成熟神经元的树突成熟。结果表明，光暗周期对新生神经元的发生和成熟有影响。此外，目前的实验可能提供一个模型，探索日光暴露，昼夜节律周期，抑郁行为之间的关系，和潜在的机制。
Recent evidence suggests that adult neurogenesis contributes to the pathophysiology of different psychiatric disorders, including depressive disorder, anxiety disorder, and schizophrenia. Seasonal affective disorder (SAD) is a specific form of recurrent depressive disorder that can be induced by shortened light period. It is unclear yet whether neurogenesis is affected in SAD or under altered light/dark cycle. The present study aims at examining whether neurogenesis and dendritic growth of immature neurons are affected in Mongolian gerbils, a mainly diurnal rodent, under light deprivation. Animals were divided into two groups: the control (kept in 12 h light: 12 h dark) and the light-deprived groups (kept in 24 h dark). Depression-like behaviors and neurogenesis were assessed after 2 weeks. Compared with the control group, light-deprived gerbils showed increased immobile time in the tail suspension test and forced swimming test, which indicates induction of depression-like behavior. Cell proliferation in both the hippocampal and subventricular zone were significantly decreased in the light-deprived group, which also showed a decreased neuronal differentiation. Dendritic maturation of immature neurons was suppressed by light deprivation, which is revealed by doublecortin staining and Sholl analysis. The results revealed that the light/dark cycle exerts impacts on neurogenesis and maturation of new neurons. Additionally, the current experiment may offer a model for exploring the relationship among daylight exposure, circadian cycles, depressive behavior, and the underlying mechanisms.