Highly precise eye length measurements in children aged 3 through 12 years
Highly precise eye length measurements in children aged 3 through 12 years
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DOI：
10.1001/archopht.121.7.985
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发表时间：
2003-07-01
影响因子：
--
通讯作者：
Stone, RA
中科院分区：
文献类型：
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作者：
Quinn, GE;Francis, EL;Stone, RA
目的：确定使用部分相干干涉测量法（一种检测眼睛各层干涉图案的非接触式方法）测量幼儿眼轴长度的可行性、可靠性和有效性。方法：测量了 64 名受试者（平均年龄 8.4 岁；年龄范围 3.4-12.9 岁；最佳矫正视力大于或等于 20/30）的右眼。受试者单眼注视激光二极管（对准光束）发出的准直光图案，操作员使用视频监视器来对准光路中的角膜反射。使用与激光二极管同轴对准的准直短相干超发光二极管的干涉图案，在 0.8 秒扫描期间测量轴向长度。获得五个系列，每个系列 16 个读数。计算 5 个系列读数中每一个读数的平均眼轴长度。主要结果测量：眼轴长度。结果：受试者内眼轴长度测量的精度很高，在 5 个疗程中各个受试者的总体测量 SE 为 8 微米（95% 置信区间，16 微米）。亚组分析表明，性别、年龄、球镜当量和屈光不正对精确度有统计学上的显着影响，但亚组之间的所有差异均为 3 µm 或更少，并且在临床上可能不显着。通过部分相干干涉测量法测量的眼轴长度存在系统性差异，已知影响眼长的因素（即年龄和屈光不正）进一步验证了测量方法。结论：部分相干干涉测量技术为幼儿提供了可重复且极其精确的眼长测量，并应为研究眼睛生长和屈光发育提供新方法。
Objective: To determine the feasibility, reliability, and validity of using partial coherence interferometry, a noncontact method that detects interference patterns from various layers of the eye, to measure axial length in young children.Methods: The right eye of 64 subjects (mean age, 8.4 y; age range, 3.4-12.9 y; best-corrected visual acuity greater than or equal to20/30) was measured. Subjects fixated monocularly on the collimated light pattern from a laser diode (the alignment beam) and the operator used a video monitor to align the corneal reflection in the optical path. Axial length was measured during an 0.8-second scan using interference patterns from a collimated short coherence superluminescence diode aligned coaxially with the laser diode. Five series of 16 readings each were obtained. The average axial length for each of the 5 series of readings was calculated.Main Outcome Measure: Axial length.Results: Within-subject precision of axial length measurements was high, with an overall SE of measurement of 8 mum for individual subjects across the 5 sessions (95% confidence interval, 16 mum). Subgroup analysis showed that sex, age, spherical equivalent, and refractive error exerted statistically significant effects on precision, but all of the differences among subgroups were 3 mum or less and likely to be insignificant clinically. Axial length measured by partial coherence interferometry varied systematically, with factors known to influence eye length (ie, age and refractive error), further validating the measurement method.Conclusion: The partial coherence interferometry technique provides reproducible, extraordinarily precise eye length measurements in young children and should enable novel approaches to study eye growth and refractive development.