Fascicles and the interfascicular matrix show decreased fatigue life with ageing in energy storing tendons.
Fascicles and the interfascicular matrix show decreased fatigue life with ageing in energy storing tendons.
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DOI：
10.1016/j.actbio.2017.03.024
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发表时间：
2017-07-01
影响因子：
9.7
通讯作者：
Screen HRC
中科院分区：
文献类型：
--
作者：
Thorpe CT;Riley GP;Birch HL;Clegg PD;Screen HRC
肌腱由束间基质（IFM）结合在一起的绳状束组成。IFM对于能量储存肌腱的功能是至关重要的，其促进了束之间的滑动以允许这些肌腱周期性地伸展和回缩。在定位钢筋束中，这种能力的要求程度较低。我们以前已经证明，在能量存储肌腱的束和IFM具有上级的抗疲劳性相比，位置肌腱，但这些不同的肌腱亚基的疲劳性能的老化的影响尚未确定。随着年龄的增长，储能肌腱变得更容易受伤，这表明疲劳抗力降低，因此我们测试了IFM中储能肌腱疲劳寿命随年龄增长而下降的假设。我们进一步假设，肌腱亚单位的抗疲劳性不会随着位置肌腱的老化而改变。对新、旧两种储能定位筋的束和IFM进行循环疲劳试验，直至失效，并计算力学性能。结果表明，IFM和来自SDFT的束都表现出相似的疲劳寿命随老化而降低的幅度。相比之下，位置肌腱亚单位的疲劳寿命不受老化的影响。与年龄相关的能量储存肌腱中肌腱亚单位疲劳寿命的下降可能导致老年肌腱损伤风险的增加。充分了解导致疲劳寿命缩短的机制将有助于开发预防年龄相关性肌腱病的治疗和干预措施。了解老化对肌腱结构功能关系的影响对于制定有效的预防措施和治疗与年龄相关的肌腱损伤至关重要。在这项研究中，我们首次证明了束间基质的抗疲劳性随着储能肌腱的老化而降低。这可能会增加老年肌腱损伤的风险。充分了解导致这种疲劳抵抗力降低的机制将有助于开发预防年龄相关性肌腱病的治疗和干预措施。
Tendon is composed of rope-like fascicles bound together by interfascicular matrix (IFM). The IFM is critical for the function of energy storing tendons, facilitating sliding between fascicles to allow these tendons to cyclically stretch and recoil. This capacity is required to a lesser degree in positional tendons. We have previously demonstrated that both fascicles and IFM in energy storing tendons have superior fatigue resistance compared with positional tendons, but the effect of ageing on the fatigue properties of these different tendon subunits has not been determined. Energy storing tendons become more injury-prone with ageing, indicating reduced fatigue resistance, hence we tested the hypothesis that the decline in fatigue life with ageing in energy storing tendons would be more pronounced in the IFM than in fascicles. We further hypothesised that tendon subunit fatigue resistance would not alter with ageing in positional tendons. Fascicles and IFM from young and old energy storing and positional tendons were subjected to cyclic fatigue testing until failure, and mechanical properties were calculated. The results show that both IFM and fascicles from the SDFT exhibit a similar magnitude of reduced fatigue life with ageing. By contrast, the fatigue life of positional tendon subunits was unaffected by ageing. The age-related decline in fatigue life of tendon subunits in energy storing tendons is likely to contribute to the increased risk of injury in aged tendons. Full understanding of the mechanisms resulting in this reduced fatigue life will aid in the development of treatments and interventions to prevent age-related tendinopathy. Understanding the effect of ageing on tendon-structure function relationships is crucial for the development of effective preventative measures and treatments for age-related tendon injury. In this study, we demonstrate for the first time that the fatigue resistance of the interfascicular matrix decreases with ageing in energy storing tendons. This is likely to contribute to the increased risk of injury in aged tendons. Full understanding of the mechanisms that result in this reduced fatigue resistance will aid in the development of treatments and interventions to prevent age-related tendinopathy.