Infertile men older than 40 years are at higher risk of sperm DNA damage
Infertile men older than 40 years are at higher risk of sperm DNA damage
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DOI：
10.1186/1477-7827-12-103
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发表时间：
2014-11-20
影响因子：
4.4
通讯作者：
Sabanegh, Edmund
中科院分区：
文献类型：
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作者：
Alshahrani, Saad;Agarwal, Ashok;Sabanegh, Edmund
背景：父亲的年龄对精液质量的影响存在争议。本研究旨在探讨男性不育症患者年龄增长对精子活性氧(ROS)、总抗氧化能力(TAC)和精子DNA损伤等精子参数的影响。我们还检查了父亲的40岁年龄是否与精子DNA损伤的风险更高相关。方法：总共472名表现为不育症的男性分为4个年龄组：A组：40岁患者的精子DNA损伤水平(24.4+/-18.5%)高于年轻男性(24.4%+/-18.5%)。
Background: The effect of paternal age on semen quality is controversial. In this retrospective study, the aim was to investigate the effects of advancing age on sperm parameters including reactive oxygen species (ROS), total antioxidant capacity (TAC) and sperm DNA damage in infertile men. We also examined whether paternal age >40 y is associated with higher risk of sperm DNA damage.Methods: A total of 472 infertile men presenting for infertility were divided into 4 age groups: group A: patients 40 y showed higher levels of sperm DNA damage (24.4 +/- 18.5%) compared to younger men (