Report from the National Institute of Allergy and Infectious Diseases workshop on "Atopic dermatitis and the atopic march: Mechanisms and interventions''
Report from the National Institute of Allergy and Infectious Diseases workshop on "Atopic dermatitis and the atopic march: Mechanisms and interventions''
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DOI：
10.1016/j.jaci.2019.01.003
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发表时间：
2019-03-01
影响因子：
14.2
通讯作者：
Plaut, Marshall
中科院分区：
文献类型：
--
作者：
Davidson, Wendy F.;Leung, Donald Y. M.;Plaut, Marshall
特应性皮炎（AD）影响全世界高达20%的儿童，是一个日益严重的公共卫生问题，特别是在发达国家。虽然婴儿和幼儿的阿尔茨海默病可以缓解，但人们普遍认为，从阿尔茨海默病到其他特应性疾病（包括食物过敏（FA）、过敏性鼻炎、过敏性哮喘和过敏性鼻结膜炎）的顺序进展风险增加，这一过程被称为特应性进行。阿尔茨海默病的发展和随后发展为其他特应性合并症（特别是FA）的机制尚不完全清楚，目前正在进行深入研究。其他主要的研究目标是开发有效的策略来预防AD和FA，以及治疗干预来抑制特应性行军。2017年，美国国家过敏和传染病研究所过敏、免疫学和移植部主办了一次研讨会，讨论当前对这些研究领域的理解和重要进展，并确定知识和未来研究方向的差距。来自几个国家卫生研究所的代表参加了该领域的国际和国内专家。本文介绍了研讨会演讲的摘要、主要结论和建议。
Atopic dermatitis (AD) affects up to 20% of children worldwide and is an increasing public health problem, particularly in developed countries. Although AD in infants and young children can resolve, there is a well-recognized increased risk of sequential progression from AD to other atopic diseases, including food allergy (FA), allergic rhinitis, allergic asthma, and allergic rhinoconjunctivitis, a process referred to as the atopic march. The mechanisms underlying the development of AD and subsequent progression to other atopic comorbidities, particularly FA, are incompletely understood and the subject of intense investigation. Other major research objectives are the development of effective strategies to prevent AD and FA, as well as therapeutic interventions to inhibit the atopic march. In 2017, the Division of Allergy, Immunology, and Transplantation of the National Institute of Allergy and Infectious Diseases sponsored a workshop to discuss current understanding and important advances in these research areas and to identify gaps in knowledge and future research directions. International and national experts in the field were joined by representatives from several National Institutes of Health institutes. Summaries of workshop presentations, key conclusions, and recommendations are presented herein.