The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies
The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies
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DOI：
10.1056/nejm199306243282508
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发表时间：
1993-06
期刊：
影响因子：
--
通讯作者：
S. Friedman
中科院分区：
文献类型：
--
作者：
S. Friedman
肝纤维化是由许多原因引起的慢性肝损伤的常见反应，包括酒精，持续的病毒和蠕虫感染，以及遗传性金属过载。新出现的证据表明，肝纤维化的细胞机制之间共享这些不同的侮辱，而且，肝脏的反应是一个范例，在其他组织的实质伤口愈合。肝细胞的分离和表征的进展，结合基质和细胞因子生物学的进展，已经导致了关于肝纤维化的细胞基础的重要新见解。特别是，肝脂肪细胞（也称为星状，脂肪储存，窦周，或伊藤。. .
Hepatic fibrosis is a common response to chronic liver injury from many causes, including alcohol, persistent viral and helminthic infections, and hereditary metal overload. Emerging evidence suggests that cellular mechanisms of hepatic fibrosis are shared among these different insults and, moreover, that the liver's response is a paradigm for parenchymal wound healing in other tissues. Advances in the isolation and characterization of liver cells, in conjunction with progress in matrix and cytokine biology, have led to important new insights about the cellular basis of hepatic fibrosis. In particular, the hepatic lipocyte (also known as the stellate, fat-storing, perisinusoidal, or Ito . . .