A neural circuit for gamma-band coherence across the retinotopic map in mouse visual cortex.
A neural circuit for gamma-band coherence across the retinotopic map in mouse visual cortex.
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DOI：
10.7554/elife.28569
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发表时间：
2018-02-26
期刊：
影响因子：
7.7
通讯作者：
Adesnik H
中科院分区：
文献类型：
--
作者：
Hakim R;Shamardani K;Adesnik H
皮质伽马振荡与各种认知、行为和回路水平现象有关。然而，γ-波段的产生和同步跨皮层空间的电路机制仍然不确定。使用小鼠视觉皮层的急性脑切片中的光遗传学图案化照明，我们定义了由层2/3（L2/3）锥体细胞和生长抑素（SOM）中间神经元组成的电路，其在视网膜定位图上锁相合奏。这里产生的网络振荡出现从非周期性的刺激，是刺激大小依赖性的，连贯的皮层空间，窄带（30 Hz），并依赖于SOM神经元，但不是小清蛋白（PV）神经元的活动，类似于视觉诱导的γ振荡在体内观察到。在不同的皮层位置产生的伽马振荡表现出高相干性，远至850 μm，和横向伽马夹带依赖于SOM神经元的活动。这些数据确定了一个电路，足以调解在初级视觉皮层的长距离伽马-波段相干性。
Cortical gamma oscillations have been implicated in a variety of cognitive, behavioral, and circuit-level phenomena. However, the circuit mechanisms of gamma-band generation and synchronization across cortical space remain uncertain. Using optogenetic patterned illumination in acute brain slices of mouse visual cortex, we define a circuit composed of layer 2/3 (L2/3) pyramidal cells and somatostatin (SOM) interneurons that phase-locks ensembles across the retinotopic map. The network oscillations generated here emerge from non-periodic stimuli, and are stimulus size-dependent, coherent across cortical space, narrow band (30 Hz), and depend on SOM neuron but not parvalbumin (PV) neuron activity; similar to visually induced gamma oscillations observed in vivo. Gamma oscillations generated in separate cortical locations exhibited high coherence as far apart as 850 μm, and lateral gamma entrainment depended on SOM neuron activity. These data identify a circuit that is sufficient to mediate long-range gamma-band coherence in the primary visual cortex.