Effect of Irradiation on the Human Laryngeal Glands
Effect of Irradiation on the Human Laryngeal Glands
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DOI：
10.1177/000348940811701005
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发表时间：
2008-10-01
影响因子：
1.4
通讯作者：
Nakashima, Tadashi
中科院分区：
文献类型：
--
作者：
Sato, Kiminori;Nakashima, Tadashi
目的：方法：应用光镜和透射电镜观察人喉腺的放射损伤情况，结果：放射治疗后较短时间内，喉腺浆液和粘液细胞胞浆内颗粒状内质网和高尔基体稀疏，放射治疗后较短时间内，浆液和粘液细胞胞浆内颗粒状内质网和高尔基体稀疏，放射治疗后较短时间内，浆液和粘液细胞胞浆内颗粒状内质网和高尔基体稀疏。浆液细胞分泌颗粒减少。分泌颗粒的电子密度较低，在非辐照标本相比，但电子透明。粘液细胞中的粘液原小滴不像未照射标本中的粘液原小滴那么多。分泌颗粒和粘液滴的分泌减少。放疗后较长时间者，胞浆内可见颗粒状内质网和高尔基体。然而，分泌颗粒和粘液原滴的透射电镜观察结果与放疗后短时间内照射的腺体相同。结论：放射性喉腺的形态学改变不仅影响分泌物的数量，而且影响分泌物的质量。上述变化使声带的润滑作用减弱，从而造成一定程度的嗓音障碍。局部免疫和粘膜纤毛运输也受到影响。放射线对喉腺的影响部分改变了喉功能。
Objectives: The present study was conducted to determine the effects of irradiation on the human laryngeal glands.Methods: Light and transmission electron microscopic observations were made.Results: Granular endoplasmic reticula and Golgi apparatuses were sparse in the cytoplasm of serous and mucous cells in cases with a short duration after radiotherapy. The secretory granules in serous cells had decreased in number. The secretory granules were less electron-dense compared to those in non-irradiated specimens, but were electron-lucent. The mucigen droplets in mucous cells were not as numerous as those in non-irradiated specimens. The discharge of secretory granules and mucigen droplets had decreased. In cases with a long duration after radiotherapy, there were some granular endoplasmic reticula and Golgi apparatuses in the cytoplasm. However, the transmission electron microscopy findings of secretory granules and mucigen droplets were the same as those in the irradiated glands with a short duration after radiotherapy.Conclusions: Morphological changes in the irradiated laryngeal glands influenced not only the amount but also the quality of secretions. The above changes lessened the lubrication of the vocal folds, thus causing a voice disorder to some extent. Local immunity and mucociliary transport were also affected. The effects of irradiation on the laryngeal glands partially altered the laryngeal functions.