SYSTEM IDENTIFIABILITY BASED ON POWER-SERIES EXPANSION OF SOLUTION

SYSTEM IDENTIFIABILITY BASED ON POWER-SERIES EXPANSION OF SOLUTION
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DOI:
10.1016/0025-5564(78)90063-9
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发表时间:
1978-01-01
影响因子:
4.3
通讯作者:
POHJANPALO, H
POHJANPALO, H
中科院分区:
生物学4区
文献类型:
--
作者:
POHJANPALO, H

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考虑状态空间表示中系统的可识别性。该分析基于系统方程可以表述为初值问题的假设。结果的应用以非线性系统为例,描述了药代动力学中常见的 2 种饱和类型:Langmuir 饱和度和 Michaelis-Menten 饱和度。在线性系统的特殊情况下,获得了一种确定可识别性的新方法。
The identifiability of systems in a state space representation is considered. The analysis is based on the assumption that the system equation can be formulated as an initial value problem. The application of the results is exemplified for nonlinear systems describing 2 frequently appearing types of saturation encountered in pharmacokinetics: Langmuir and Michaelis-Menten saturation. In the special case of linear systems a new way to determine the identifiability is obtained.