THE COMBINED EFFECTS OF N-3 FATTY-ACIDS AND ASPIRIN ON HEMOSTATIC PARAMETERS IN MAN
THE COMBINED EFFECTS OF N-3 FATTY-ACIDS AND ASPIRIN ON HEMOSTATIC PARAMETERS IN MAN
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DOI：
10.1016/0049-3848(90)90069-o
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发表时间：
1990-02-15
影响因子：
7.5
通讯作者：
DUJOVNE, CA
中科院分区：
文献类型：
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作者：
HARRIS, WS;SILVEIRA, S;DUJOVNE, CA
鱼油和阿司匹林都可以作为非处方制剂容易地提供给消费者。由于这两种产品均显示可延长出血时间，因此联合使用这两种产品的受试者可能会对止血产生不良影响。本研究旨在检测n-3脂肪酸和阿司匹林对血小板功能的影响。8名健康男性在开始两周鱼油补充（4.5 g n-3脂肪酸/天）之前，在3天内服用了总共485 mg阿司匹林。受试者继续服用鱼油，同时恢复阿司匹林治疗3天。单独使用阿司匹林使出血时间延长34%（p < 0.05）。单独使用鱼油仅略微增加出血时间（9%; N.S.），而阿司匹林加鱼油则提高了78%（P < 0.01）。联合用药的出血时间增加（78%）与单个增加的总和（43%）无显著差异。使用单一和双重激动剂研究鱼油和阿司匹林对血小板聚集的影响。虽然单独的鱼油并没有显著提高胶原蛋白、花生四烯酸或PAF的聚集阈值，但它确实降低了胶原蛋白的聚集程度。当受到单一或双重激动剂的挑战时，鱼油和阿司匹林的组合并没有使血小板比阿司匹林单独敏感。由于鱼油和阿司匹林对出血时间有协同作用，但对血小板聚集无协同作用，因此这两种物质似乎通过不同的机制影响止血作用。
Both fish oils and aspirin are readily available to the consumer as over-the-counter preparations. Since both of these products have been shown to pprolong bleeding simtes, it is possible that hemostasis might be adversely affected in subjects taking them in combination. This study was undertaken to examine the effects of n-3 fatty acids and aspirin on platelet function. Eight healthy men took a total of 485 mg of aspirin over 3 days before beginning two weeks of fish oil supplementation (4.5 g of n-3 fatty acids/day). Subjects continued with fish oil while resuming aspirin treatment for 3 days. Aspirin alone prolonged bleeding times by 34% (p < 0.05). Fish oil alone raised bleeding times only slightly (9%; N.S.), but aspirin plus fish oil raised them by 78% (p < 0.01). The increase in bleeding times with the combination (78%) was not significantly different than the sum of the individual increases (43%). The effects of fish oil and aspirin on platelet aggregation were investigated using single and dual agonists. Although fish oil alone did not significantly raise aggregation thresholds for collagen, arachidonic acid, or PAF, it did reduce the extent of aggregation with collagen. When challenged by single of dual agonists, the combination of fish oil and aspirin did not make platelets less sensitive than did aspirin alone. Since fish oil and aspirin had synergistic effects on bleeding times, but not on platelet aggregation, there two substances appear to affect hemostatis by different mechanisms.