Comparative split‐face study of durational changes in hyaluronic acid fillers for mid‐face volume augmentation
Comparative split‐face study of durational changes in hyaluronic acid fillers for mid‐face volume augmentation
复制标题
透明质酸填充剂用于中面部体积增大的持续变化的比较分体研究
DOI：
10.1111/dth.12950
复制
发表时间：
2019
影响因子：
3.6
通讯作者：
C. Youn
中科院分区：
文献类型：
--
作者：
K. Park;J. M. Kim;J. Seok;S. Seo;M. Kim;C. Youn
在确定注射真皮填充物的精确体积时，应考虑注射后的后续变化。一些研究使用评分系统来评估面部体积;然而，这些评分系统不是特别客观。本研究旨在评价三维（3D）图像上随时间推移的体积变化以及用于面中部体积增大的各种透明质酸（HA）填充物的维持潜力。该分面临床研究包括9名韩国受试者，每名受试者均在一侧面中部注射试验填充物（B），在对侧注射随机对照填充物（J、R或Y）。在基线和30分钟、3天、2、4、12和24周后进行总体、摄影和3D扫描评估。在所有9个病例中，3D图像显示注射测试填充物（B）的高度差异最大。主观评分系统的结果与3D成像的结果相关。双相填料（B和J）的体积比双相填料（R和Y）的体积保持更长的时间。B填料产生了优异的增稠和铺展效果以及良好的可注射性。这种填充物适合注射到高压区域，例如侧颊、下巴和鼻唇沟。此外，三维成像分析提供了客观和数字化的数据。本作者希望他们的数据将使医生更好地了解HA填充物的持续时间变化，从而为患者提供准确的预测。
Subsequent changes after injection should be considered when determining the precise volume of injected dermal filler. Several studies have used scoring systems to evaluate facial volumes; however, these scoring systems are not particularly objective. This present study aimed to evaluate the volumetric changes over time on three‐dimensional (3D) images and the maintenance potential of various hyaluronic acid (HA) fillers used for mid‐face volume augmentation. This split‐face clinical study included nine Korean subjects who each received a mid‐facial injection of the test filler (B) on one side and a random control filler (J, R, or Y) on the contralateral side. Global, photographic, and 3D scanning assessments were conducted at baseline and after 30 min, 3 days, and 2, 4, 12, and 24 weeks. In all nine cases, the 3D images revealed the largest differences in height where the test filler (B) was injected. The results of subjective scoring systems correlated with the results of 3D imaging. The volumes of monophasic fillers (B and J) were maintained for longer periods of time than those of biphasic fillers (R and Y). The B filler yielded excellent volumizing and spreading effects and good injectability. This filler would be suitable for injection into high‐pressure areas, such as the lateral cheek, chin, and nasolabial fold. Moreover, the 3D imaging analysis provided objective and digitized data. The present authors hope that their data will allow physicians to better understand the durational changes in HA fillers and, thus, provide accurate predictions to their patients.