Intermittent hypoxia damages cerebellar cortex and deep nuclei
Intermittent hypoxia damages cerebellar cortex and deep nuclei
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DOI：
10.1016/j.neulet.2004.10.091
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发表时间：
2005-02-28
影响因子：
2.5
通讯作者：
Harper, RM
中科院分区：
文献类型：
--
作者：
Pae, EK;Chien, P;Harper, RM
Obstructive sleep apnea patients show cerebellar cortex and deep nuclei gray matter loss, a possible consequence of intermittent hypoxia (IH) accompanying the syndrome. We exposed prague-Dawley rats (n = 24) to room air only or 10.3% O-2, balance N-2, alternating every 480s (240s duty cycle) with room air for 5, 10, 15, 20 or 30 h (7.5 h per day) during light periods. IH-exposed rats showed increased numbers of damaged Purkinje cells (31.1, 50.5, 54.7, 65.2 and 94.4% for 5, 10, 15, 20 and 30 h groups, respectively; p < 0.001 for slopes of the total, swollen/autolysed, and shrunken/dark cell counts), as assessed by hematoxylin and eosin staining. Anti-caspase-3 antibody density increased in the fastigial nuclei subsequent to 5-h exposure. Short-term IH exposure elicits dose-dependent cerebellar Purkinje and fastigial neuron damage. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
