RETENTION OF TOPICAL LIPOSOMAL FORMULATIONS ON THE CORNEA
RETENTION OF TOPICAL LIPOSOMAL FORMULATIONS ON THE CORNEA
复制标题
DOI：
10.1007/bf01939943
复制
发表时间：
1990-07-15
期刊：
影响因子：
--
通讯作者：
LEVY, M
中科院分区：
文献类型：
--
作者：
MCCALDEN, TA;LEVY, M
本文研究了由不同磷脂材料组成的脂质体在兔角膜表面的黏附能力。脂质体被标记有示踪量的I125标记的磷脂酰乙醇胺衍生物，并以10µl滴注到角膜上。监测放射性滞留情况。结果表明，与白蛋白对照相比，含有正电荷磷脂的脂质体具有更好的保存性。因此，有可能开发一种允许眼科药物长期持续释放到角膜上的药物递送脂质体系统。
The ability of liposomes composed of different kinds of phospholipid materials to adhere to the surface of the cornea was studied in the rabbit. The liposomes were labelled with tracer amounts of an I125-labelled phosphatidylethanolamine derivative and were instilled in 10 .mu.l drops onto the cornea. The retention of radioactivity was monitored. The results show that liposomes containing positively charged phospholipids are better retained than an albumin control. Thus, it may be possible to develop a drug delivery liposome system which would permit long-term sustained release of ophthalmic drugs onto the cornea.