Twenty-four hour melatonin pattern in acromegaly: Effect of acute octreotide administration
Twenty-four hour melatonin pattern in acromegaly: Effect of acute octreotide administration
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DOI：
10.1007/bf03346890
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发表时间：
1997-03-01
影响因子：
5.4
通讯作者：
Bellastella, A
中科院分区：
文献类型：
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作者：
Sinisi, AA;Pasquali, D;Bellastella, A
我们调查了10名患有垂体微腺瘤所致活动性肢端肥大症的受试者（4名男性，6名女性; 23-52岁）在生长抑素（奥曲肽）急性给药前后的褪黑激素（MT）昼夜节律。在48小时内每2小时抽取血样;在24小时基础血液采集后，给予奥曲肽（Sandostatin，Sandoz）100 μ g sc/8小时。作为对照，7名健康成年受试者（3名男性，4名女性; 26-50岁）在基础条件下进行了24小时的研究。采用放射免疫分析法测定各组患者血浆MT和GH水平，采用免疫放射分析法测定基础和奥曲肽治疗后晨检患者血清IGF-1水平。通过Mann-U-Whitney和Wilcoxon检验进行适当的比较;通过余弦分析验证MT昼夜节律的存在; GH和MT值通过Pearson相关系数进行相关。7例正常人和10例肢端肥大症患者中的2例均有明显的24小时MT节律。肢端肥大症患者MT节律的曲线下面积（AUC）、中位值（mesor）和振幅均显著低于对照组（p
We investigated the melatonin (MT) circadian rhythm before and after somatostatin (octreotide) acute administration in ten subjects (4 M, 6 F; 23-52 yr old) with active acromegaly due to pituitary microadenoma. Blood samples were drawn every 2 hours over a 48-h span; after 24-h basal blood collection, octreotide (Sandostatin, Sandoz) 100 mu g sc/8 h was administered. As control, 7 healthy adult subjects (3M, 4F; 26-50 yr old) were studied in basal condition over a 24-h span. Plasma MT and GH levels were measured by RIA in each sample, IGF-1 levels were measured by immunoradiometric assay in basal and after octreotide morning samples. The comparisons were made by Mann-U-Whitney and Wilcoxon test as appropriate; the existence of a MT circadian rhythm was validated by cosinor analysis; GH and MT values were correlated by Pearson's correlation coefficient. All of 7 control subjects and 2 of 10 acromegalics had significant 24-h MT rhythm. The area under curve (AUC), mesor and amplitude of the MT rhythms in acromegalics were significantly lower than in the controls (p