Over-the-counter sympathomimetics: a risk factor for cardiac arrhythmias in pregnancy.
Over-the-counter sympathomimetics: a risk factor for cardiac arrhythmias in pregnancy.
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DOI：
10.1097/00007611-199812000-00011
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发表时间：
1998-12
影响因子：
1.1
通讯作者：
Macaulay Onuigbo;Mahmood Alikhan
中科院分区：
文献类型：
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作者：
Macaulay Onuigbo;Mahmood Alikhan
超过170种非处方（OTC）制剂含有拟交感神经制剂作为活性成分。非处方药在我们的社会中被普遍使用。苯丙醇胺是一种肾上腺素能激动剂，也是一种流行的减充血剂，每年的消耗量高达50亿剂。据报道，非处方的拟交感神经药物可引起高血压和心律失常。尽管这些药物有可能引起这些潜在的严重不良反应，并且这些药物的大量使用，但直到最近，医学文献对不良事件的报道还很少。我们报告症状性室性心律失常和晕厥前在一个36岁的孕妇谁消耗相对高剂量的两种OTC感冒药同时。需要提高医生对非处方拟交感神经药物潜在副作用的认识，并提高患者的教育水平。最后，我们支持在一些选定的OTC制剂（包括OTC拟交感神经药物）上增加显著警告标签的呼吁。
More than 170 over-the-counter (OTC) preparations contain a sympathomimetic agent as the active ingredient. Nonprescription medicines are consumed commonly in our society. Phenylpropanolamine, an alpha-adrenergic agonist as well as a popular decongestant, is consumed at a massive volume of 5 billion doses annually. Over-the-counter sympathomimetics have been reported to cause hypertension and arrhythmias. Despite the ability to cause these potentially serious adverse effects and the high-volume consumption of these agents, the medical literature until recently has been scant in reporting adverse events. We report symptomatic ventricular arrhythmia and presyncope in a 36-year-old pregnant woman who consumed relatively high doses of two OTC cold remedies simultaneously. Increased physician awareness of the potential side effects associated with OTC sympathomimetics as well as improved level of patient education are needed. Finally, we support the calls for more prominent warning labels on some selected OTC preparations, including OTC sympathomimetics.