GD-DTPA-CASCADE-POLYMER - POTENTIAL BLOOD-POOL CONTRAST AGENT FOR MR-IMAGING
GD-DTPA-CASCADE-POLYMER - POTENTIAL BLOOD-POOL CONTRAST AGENT FOR MR-IMAGING
复制标题
DOI：
10.1002/jmri.1880040336
复制
发表时间：
1994-05-01
期刊：
影响因子：
--
通讯作者：
GUNTHER, RW
中科院分区：
文献类型：
--
作者：
ADAM, G;NEUERBURG, J;GUNTHER, RW
Gd-DTPA(二乙三胺五乙酸)-层叠聚合物是一种潜在的新的磁共振(MR)血池造影剂，在动物模型中与已知的血池造影剂Gd-DTPA-聚赖氨酸进行了比较。用闪光(快速小角度激发)序列检测12头猪注射造影剂后4秒至120分钟内肝脏、肾皮质、胰腺和躯干肌的相对信号强度。注射两种造影剂后，除肌肉外，其余组织均有明显强化。注入Gd-DTPA聚合物后。肝脏、肾皮质和胰腺的强化模式与注射Gd-DTPA-聚赖氨酸后相似。在任何时间点，两种造影剂之间的增强没有统计学意义上的差异。作者认为Gd-DTPA级联聚合物的造影剂动力学与Gd-DTPA-聚赖氨酸的造影剂相似，可作为磁共振成像的血池造影剂。
Gadolinium-DTPA (diethylenetriaminepentaacetic acid)-cascade-polymer, a potential new blood pool contrast agent for magnetic resonance (MR) imaging, was compared with a known blood pool agent, Gd-DTPA-polylysine, in an animal model. The relative signal intensities of liver, renal cortex, pancreas, and trunk muscle were assessed in 12 pigs between 4 seconds and 120 minutes after injection of a 20 mumol/kg dose of each contrast agent, by using a FLASH (fast low-angle shot) sequence. Except for muscle, all tissues showed visible enhancement after injection of either contrast agent. After injection of Gd-DTPA-polymer. enhancement patterns in the liver, renal cortex, and pancreas were similar to those seen after injection of Gd-DTPA-polylysine. No statistically significant differences in enhancement between the two contrast agents were found at any time point. The authors conclude that the contrast kinetics of Gd-DTPA-cascade-polymer are similar to those of Gd-DTPA-polylysine and that this agent may also be used as a blood pool contrast agent for MR imaging.