Hyperandrogenism exerts an anti-inflammatory effect in obese women with polycystic ovary syndrome.
Hyperandrogenism exerts an anti-inflammatory effect in obese women with polycystic ovary syndrome.
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DOI：
10.1007/s12020-012-9728-6
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发表时间：
2012-12
期刊：
影响因子：
3.7
通讯作者：
Krupa, Michelle E.
中科院分区：
文献类型：
--
作者：
Gonzalez, Frank;Sia, Chang Ling;Stanczyk, Frank Z.;Blair, Hilary E.;Krupa, Michelle E.
与体重匹配的对照组相比，我们确定了慢性雄激素抑制对多囊卵巢综合征（PCOS）女性炎症的影响。我们进行了一个试点项目，使用了以前前瞻性对照研究的样本。9名患有多囊卵巢综合征的女性（5名肥胖，4名消瘦）和9名排卵正常的女性（5名肥胖，4名消瘦）参加了这项研究。分别在使用促性腺激素释放激素（GnRH）激动剂3、6个月前后测定雄激素、c反应蛋白（CRP）、白细胞介素-6 （IL-6）、游离脂肪酸（FFA）和体重。GnRH激动剂治疗使所有受试者的雌二醇、睾酮和雄烯二酮降低到相似水平。CRP和IL-6在患有多囊卵巢综合征的肥胖女性中升高，在患有多囊卵巢综合征的瘦女性和肥胖对照组中保持不变，在治疗6个月后，在患有多囊卵巢综合征的瘦对照组中下降。肥胖多囊卵巢综合征女性的FFA下降，体重增加，但在治疗6个月后，消瘦多囊卵巢综合征女性和两组对照组的FFA均无显著变化。睾丸激素的减少与体重和IL-6的增加有关。FFA的下降与CRP的升高有关。体重和IL-6的增加与CRP的升高有关。我们认为，当肥胖存在时，多囊卵巢综合征的高雄激素血症可能发挥抗炎作用，但可能不会促进多囊卵巢综合征的炎症；循环中的雄激素对炎症有多效性作用，这取决于多囊卵巢综合征和特定个体的体重状况。
We determined the effect of chronic androgen suppression on inflammation in women with Polycystic Ovary Syndrome (PCOS) compared to weight-matched controls. We performed a pilot project using samples from previous prospective, controlled studies. Nine women with PCOS (5 obese, 4 lean) and 9 ovulatory controls (5 obese, 4 lean) participated in the study. Androgens, C-reactive protein (CRP), interleukin-6 (IL-6), free fatty acids (FFA) and body weight were measured before and after 3 and 6 months of gonadotropin releasing hormone (GnRH) agonist administration. GnRH agonist treatment decreased estradiol, testosterone and androstenedione to similar levels in all subjects. CRP and IL-6 increased in obese women with PCOS, was unaltered in lean women with PCOS and obese controls, and decreased in lean controls after 6 months of treatment. FFA decreased and body weight increased in obese women with PCOS, but did not change significantly in lean women with PCOS and in either control group after 6 months of treatment. The testosterone reduction was related to increases in weight and IL-6. The fall in FFA was related to the rise in CRP. The increases in weight and IL-6 were related to the rise in CRP. We propose that hyperandrogenism in PCOS may exert an anti-inflammatory effect when obesity is present, but may not promote inflammation in the disorder; and that circulating androgens have a pleiotropic effect on inflammation depending on the combination of PCOS and weight status in a given individual.
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