Multimodality therapy for gastroesophageal cancers.
Multimodality therapy for gastroesophageal cancers.
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胃食管癌的多学科治疗。
DOI：
10.1016/s1091-255x(02)00027-6
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Wang,KennethK
中科院分区：
文献类型：
--
作者：
Wang,KennethK
综合治疗是胃-食道口癌治疗的关键。目前，放化疗和食道切除术似乎是标准的治疗方法。选择对化疗和放射治疗完全有效的患者可能是食道切除术的最佳候选者。虽然主张扩大淋巴清扫术，但没有足够的数据来确定这种手术的发病率增加是否与交界性癌症预后的改善有关。非手术患者的早期癌症可能可以通过内窥镜方法治疗，包括内窥镜黏膜切除术和光动力疗法，前者可以进行准确的分期，后者可以治疗残留的癌前组织。晚期胃食道结合部癌症患者的姑息治疗可能是使用可膨胀金属支架的最好方法，尽管有一些证据表明，热疗方法可能会提高这些患者的生活质量。
Multimodality therapy is the key to the treatment of carcinomas of the gastroesophageal junction. Chemoradiation followed by esophagectomy appears to be the standard therapy at the present time. Selected patients who respond completely to the chemotherapy and radiation are probably the best candidates for esophagectomy. Although extended lymph node dissection is advocated, there are not sufficient data to determine whether the increased morbidity of the procedure is justified by the improvement in outcome for junctional cancers. Early cancers in nonsurgical patients could potentially be treated by endoscopic methods including endoscopic mucosal resection, which permits accurate staging, and photodynamic therapy, which permits treatment of residual premalignant tissue. Palliation of patients with advanced cancers of the gastroesophageal junction is probably best managed with expandable metal stents, although there is some evidence to suggest that thermal methods of palliation may enhance the quality of life in these patients.
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DOI：
10.1016/s1278-3218(02)00178-6
发表时间：
2002-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
J. Macdonald;S. Smalley;J. Benedetti;S.A Hundhal;N. Estes;G.N Stemmermannn;D. Haller;J. Ajani-
通讯作者：
J. Macdonald;S. Smalley;J. Benedetti;S.A Hundhal;N. Estes;G.N Stemmermannn;D. Haller;J. Ajani-
影响因子：
45.3
作者：
Tepper, Joel;Krasna, Mark J.;Mayer, Robert
通讯作者：
Mayer, Robert
派姆单抗 (MK-3475) 与安慰剂在接受化疗和放疗的食管癌参与者中的研究 (MK-3475-975/KEYNOTE-975)
DOI：
10.31525/ct1-nct04210115
发表时间：
2019
期刊：
Case Medical Research
影响因子：
--
作者：
Demetria M. McNeal;O. J. Sahler;R. Noll;D. Fairclough;Megan E. Voll;Shubha Bhat;E. Morrato
通讯作者：
E. Morrato
影响因子：
45.3
作者：
Stroes, Charlotte, I;Schokker, Sandor;van Laarhoven, Hanneke W. M.
通讯作者：
van Laarhoven, Hanneke W. M.
影响因子：
45.3
作者：
Smalley, Stephen R.;Benedetti, Jacqueline K.;Macdonald, John S.
通讯作者：
Macdonald, John S.