Carbapenem-Resistant Enterobacteriaceae Infections in Children.
Carbapenem-Resistant Enterobacteriaceae Infections in Children.
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DOI：
10.1007/s11908-015-0510-9
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发表时间：
2016-01
影响因子：
3.1
通讯作者：
Tamma PD
中科院分区：
文献类型：
--
作者：
Chiotos K;Han JH;Tamma PD
耐碳青霉烯类肠杆菌科（CRE）是一种新兴的全球公共卫生威胁。CRE引起的感染与显著的发病率和死亡率相关。很少有治疗选择可用于治疗这些感染，最佳抗生素治疗方案尚不清楚。沿着CRE在美国和世界范围内的迅速增加的患病率，一些研究已经描述了CRE在成人人群中的流行病学。虽然CRE现在在儿童中也有零星报道，但在这一人群中流行病学，风险因素，治疗和结果方面的数据严重缺乏。本文提供了一个全面的审查是什么是已知的CRE，包括临床和分子流行病学，微生物学诊断，抗生素治疗方案和结果。特别是，本次审查将集中在现有的数据对CRE在儿科人口。
Carbapenem-resistant Enterobacteriaceae (CRE) are an emerging global public health threat. Infections due to CRE are associated with significant morbidity and mortality. Few therapeutic options are available for treatment of these infections, and optimal antibiotic treatment regimens are unclear. Along with the rapidly increasing prevalence of CRE in the United States and worldwide, several studies have described the epidemiology of CRE in the adult population. While CRE is now also reported sporadically in children, there is a significant lack of data on the epidemiology, risk factors, treatment, and outcomes in this population. This article provides a comprehensive review of what is known to date about CRE, including clinical and molecular epidemiology, microbiologic diagnosis, antibiotic treatment options, and outcomes. In particular, this review will focus on the available data on CRE in the pediatric population.