Persistence and transition of Epstein-Barr virus genotypes in the pathogenesis of oral hairy leukoplakia.
Persistence and transition of Epstein-Barr virus genotypes in the pathogenesis of oral hairy leukoplakia.
复制标题
口腔毛状白斑发病机制中 Epstein-Barr 病毒基因型的持续存在和转变。
DOI：
10.1086/421708
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Nichols,CMark
中科院分区：
文献类型：
--
作者：
Walling,DennisM;Etienne,Wiguins;Ray,AutumnJ;Flaitz,CatherineM;Nichols,CMark
这项前瞻性研究检测了人类免疫缺陷病毒(HIV)血清阳性患者中EB病毒(EBV)的持久性和转移性。口腔毛状白斑是一种与EB病毒相关的复制性上皮性疾病。在接受万乃洛韦治疗以抑制EBV复制的受试者中，EBV感染的宿主内分子流行病学具有特征。HIV血清阳性受试者的舌上皮组织被发现不仅支持EBV复制，而且支持持续的、非生产性的EBV感染。EB病毒似乎是从感染的血库进入舌头的，也可能是从外源进入舌头的。即使在万乃洛韦介导的EBV复制抑制期间，EBV从血液到舌头的转移似乎也发生了，这表明EBV进入舌上皮组织是一种细胞相关的潜伏感染。综上所述，这些结果将EBV的持续和转移描述为EBV感染的血液和上皮库之间的动态相互作用，并提示口腔上皮性EBV的进入、持续和重新激活在口腔毛状白斑的发病机制中发挥了作用。
This prospective study examined the persistence and transition of Epstein-Barr virus (EBV) in human immunodeficiency virus (HIV)-seropositive subjects with and without oral hairy leukoplakia, a replicative EBV associated epithelial disease. The intrahost molecular epidemiology of EBV infection was characterized in subjects treated with valacyclovir to suppress EBV replication. Tongue epithelial tissues of HIV-seropositive subjects were found to support not only EBV replication but also persistent, nonproductive EBV infection. EBV appeared to enter the tongue from the blood reservoir of infection and, possibly, from exogenous sources as well. EBV transition from the blood to the tongue appeared to occur even during valacyclovir-mediated suppression of EBV replication, suggesting EBV entry into tongue epithelial tissue as a cell-associated latent infection. In conclusion, these results describe the persistence and transition of EBV as a dynamic interaction between the blood and epithelial reservoirs of EBV infection and suggest a role for entry, persistence, and reactivation of oral epithelial EBV in the pathogenesis of oral hairy leukoplakia.