Importance of vertical and horizontal transmission of West Nile virus by Culex pipiens in the northeastern United States
Importance of vertical and horizontal transmission of West Nile virus by Culex pipiens in the northeastern United States
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DOI：
10.1086/508754
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发表时间：
2006-12-01
影响因子：
6.4
通讯作者：
Main, Andy J.
中科院分区：
文献类型：
--
作者：
Anderson, John F.;Main, Andy J.
西尼罗河病毒 (WNV) 已在美国东北部扎根，那里的蚊子在冬季不活跃。目前还没有记录在案的研究来解释这种病毒如何在冬季存活并在春季重新开始感染。我们报告说，西尼罗河病毒是从康涅狄格州斯特拉特福收集的自然感染雌性库蚊中垂直传播给 2 只 F-1 雌性淡色库蚊的。一只 168 天大的垂直感染 F-1 雌性以一只仓鼠为食，该仓鼠在 8 天后死于西尼罗河病。这表明西尼罗河病毒在未喂食、垂直感染的淡色隐孢子虫中存活下来，并在春季通过水平传播开始扩增。
West Nile virus (WNV) has become established in the northeastern United States, where mosquitoes are inactive during winter. There have been no documented studies to explain how this virus survives winter and reinitiates infection in spring. We report that WNV was vertically transmitted to 2 F-1 female Culex pipiens from a naturally infected female collected in Stratford, Connecticut. One vertically infected F-1 female, which was 168 days old, fed on a hamster that died 8 days later of West Nile disease. This suggests that WNV survives winter in unfed, vertically infected C. pipiens with amplification initiated in spring by horizontal transmission.