Interrelationship Between Periapical Lesion and Systemic Metabolic Disorders.
Interrelationship Between Periapical Lesion and Systemic Metabolic Disorders.
复制标题
DOI：
10.2174/1381612822666160216145107
复制
发表时间：
2016
影响因子：
3.1
通讯作者：
Hashimoto K
中科院分区：
文献类型：
--
作者：
Sasaki H;Hirai K;Martins CM;Furusho H;Battaglino R;Hashimoto K
根尖周炎又称根尖周病，是一种常见的口腔疾病，沿着牙周炎（牙龈病）。根尖周炎是一种慢性炎症性疾病，由根管感染引起，其发展受宿主免疫/炎症反应的调节。代谢紊乱在很大程度上依赖于生活方式，如饮食习惯，已被解释为“代谢触发”的低度全身性炎症，并可能通过触发免疫调节与根尖周炎相互作用。因此，宿主免疫系统被认为是两种疾病的共同基本机制。由代谢紊乱引起的炎症状态升高会影响根尖周病变的临床结果，并干扰牙髓治疗后的伤口愈合。虽然需要额外的精心设计的临床研究，根尖周病变似乎会影响胰岛素敏感性和加重非酒精性脂肪性肝炎。免疫调节细胞因子产生的各种类型的细胞，包括免疫细胞和脂肪组织，在这种相互关系中发挥重要作用。
Periapical periodontitis, also known as periapical lesion, is a common dental disease, along with periodontitis (gum disease). Periapical periodontitis is a chronic inflammatory disease, caused by endodontic infection, and its development is regulated by the host immune/inflammatory response. Metabolic disorders, which are largely dependent on life style such as eating habits, have been interpreted as a “metabolically-triggered” low-grade systemic inflammation and may interact with periapical periodontitis by triggering immune modulation. The host immune system is therefore considered the common fundamental mechanism of both disease conditions. An elevated inflammatory state caused by metabolic disorders can impact the clinical outcome of periapical lesions and interfere with wound healing after endodontic treatment. Although additional well-designed clinical studies are needed, periapical lesions appear to affect insulin sensitivity and exacerbate non-alcoholic steatohepatitis. Immune regulatory cytokines produced by various cell types, including immune cells and adipose tissue, play an important role in this interrelationship.