The emerging concept of vascular remodeling.
The emerging concept of vascular remodeling.
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DOI：
10.1056/nejm199405193302008
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发表时间：
1994-05
期刊：
影响因子：
--
通讯作者：
G. Gibbons;V. Dzau
中科院分区：
文献类型：
--
作者：
G. Gibbons;V. Dzau
血管壁是由内皮细胞、平滑肌细胞和成纤维细胞组成的活跃的完整器官，这些细胞在复杂的自分泌-旁分泌相互作用中相互偶联。脉管系统能够感知其环境内的变化，通过细胞间通信整合这些信号，并通过影响结构和功能的介质的局部产生来改变自身。血管重塑是结构改变的主动过程，其涉及至少四种细胞过程的变化-细胞生长、细胞死亡、细胞迁移和细胞外基质的产生或降解-并且依赖于局部之间的动态相互作用。. .
The vessel wall is an active, integrated organ composed of endothelial, smooth-muscle, and fibroblast cells coupled to each other in a complex autocrine-paracrine set of interactions. The vasculature is capable of sensing changes within its milieu, integrating these signals by intercellular communication, and changing itself through the local production of mediators that influence structure as well as function. Vascular remodeling is an active process of structural alteration that involves changes in at least four cellular processes -- cell growth, cell death, cell migration, and production or degradation of extracellular matrix -- and is dependent on a dynamic interaction between locally . . .