Different Effect of Laparoscopic Roux-en-Y Gastric Bypass and Open Biliopancreatic Diversion of Scopinaro on Serum PYY and Ghrelin Levels
Different Effect of Laparoscopic Roux-en-Y Gastric Bypass and Open Biliopancreatic Diversion of Scopinaro on Serum PYY and Ghrelin Levels
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DOI：
10.1007/s11695-008-9560-5
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发表时间：
2008-11-01
期刊：
影响因子：
2.9
通讯作者：
Soriguer, F.
中科院分区：
文献类型：
--
作者：
Garcia-Fuentes, E.;Garrido-Sanchez, L.;Soriguer, F.
背景：减肥手术对肽YY （PYY）和胃饥饿素水平的影响仍在讨论中。我们同时评估了PYY和胃饥饿素的血清变化，这取决于特定类型的减肥手术。方法对29例健康患者和接受Scopinaro手术（BPD） （n=38）或腹腔镜Roux-en-Y胃旁路手术（RYGB; n=13）的病态肥胖者进行PYY和ghrelin的统计分析。结果RYGB导致的体重和体重指数下降明显大于BPD。RYGB和BPD均与PYY显著增加相关，BDP显著增加（p=0.001）。RYGB后Ghrelin显著升高（p=0.022）， BPD后无显著升高。术后PYY与体重呈正相关（r=0.416, p=0.009）。胃饥饿素与所研究的任何变量都没有显著的相关性。方差分析显示，只有手术类型对PYY （p=0.002）和ghrelin （p=0.018）的差异有显著影响。结论与RYGB相比，BPD导致PYY增加更大，体重减轻更小。然而，只有RYGB与胃饥饿素的显著增加有关。根据减肥手术类型的不同，体重减轻似乎不能用PYY和胃饥饿素的变化来解释。
Background The impact of bariatric surgery on levels of peptide YY (PYY) and ghrelin is still under discussion. We undertook a simultaneous evaluation of the serum changes in PYY and ghrelin depending on the specific type of bariatric surgery.Methods Total PYY and ghrelin were analyzed in 29 healthy persons and in morbidly obese persons undergoing open biliopancreatic diversion (BPD) of Scopinaro (n=38) or laparoscopic Roux-en-Y gastric bypass (RYGB; n=13).Results RYGB resulted in a significantly greater loss of weight and body mass index than BPD. Both RYGB and BPD were associated with a significant increase in PYY, significantly greater for BDP (p=0.001). Ghrelin rose significantly after RYGB (p=0.022) but not after BPD. After surgery, PYY correlated positively with weight (r=0.416, p=0.009). Ghrelin did not correlate significantly with any of the variables studied. Analysis of variance showed that only the type of surgery contributed significantly to explain the variances in the PYY (p=0.002) and ghrelin (p=0.018).Conclusions BPD results in a greater increase in PYY and a lower weight loss than RYGB. However, only RYGB was associated with a significant increase in ghrelin. The differing weight loss according to the type of bariatric surgery does not seem to be explained by changes arising in PYY and ghrelin.