Placental lipid metabolism in preeclampsia
Placental lipid metabolism in preeclampsia
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DOI：
10.1097/hjh.0000000000002596
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发表时间：
2021-01-01
影响因子：
4.9
通讯作者：
Joshi, Sadhana R.
中科院分区：
文献类型：
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作者：
Khaire, Amrita A.;Thakar, Shivani R.;Joshi, Sadhana R.
目的：目前的研究探讨了先兆子痫妇女胎盘和母体的脂质谱和胎盘脂质代谢相关基因的表达。方法：本研究包括正常血压对照妇女（n = 40）和先兆子痫妇女（n = 39）。先兆子痫妇女进一步分为足月先兆子痫（T-PE; n = 15）和早产先兆子痫（PT-PE; n = 24）。结果：T-PE组和正常对照组之间的母亲血脂谱没有显着差异。与正常对照组相比，PT-PE组孕妇血浆VLDL（P <0.05）、总胆固醇/高密度脂蛋白（P < 0.05）、动脉粥样硬化指数（log（甘油三酯/高密度脂蛋白））（P < 0.01）和载脂蛋白B：载脂蛋白A（P < 0.05）均升高。T-PE组胎盘总胆固醇和高密度脂蛋白水平均高于正常对照组（P < 0.05）。PT-PE组胎盘甘油三酯水平明显高于T-PE组（P < 0.05）。胎盘过氧化物酶体增殖物激活受体α、肉毒碱棕榈酰转移酶-1、分化簇36和脂蛋白脂酶的mRNA水平在PT-PE组低于正常对照组（P < 0.05）。过氧化物酶体增殖物激活受体α mRNA水平的负相关性（r =-0.246，P = 0.032; r =-0.308，P = 0.007），肉毒碱棕榈酰转移酶-1（r =-0.292，P = 0.011; r =-0.366，P = 0.001），脂蛋白脂酶（r =-0.296，P = 0.010; r =-0.254，P = 0.028）与收缩压、舒张压的关系。胎盘甘油三酯与DBP呈正相关（r = 0.244，P = 0.031）。结论：患有先兆子痫的妇女表现出较高的脂质：脂蛋白比率，提示动脉粥样硬化状态，特别是在早产的妇女中。在先兆子痫中也观察到参与胎盘脂肪酸氧化和转运的基因表达降低。
Objectives: The current study examines the placental and maternal lipid profile and expression of genes involved in placental lipid metabolism in women with preeclampsia. Methods: The current study includes normotensive control women (n = 40) and women with preeclampsia (n = 39). Preeclampsia women were further classified into women delivering at term preeclampsia (T-PE; n = 15) and preterm preeclampsia (PT-PE; n = 24). Results: There were no significant differences in maternal lipid profile between the T-PE and normotensive control groups. Maternal plasma VLDL (P < 0.05) and ratios of total cholesterol : HDL (P < 0.05), atherogenic index [log (triglycerides/HDL)] (P < 0.01) and apolipoprotein B : apolipoprotein A (P < 0.05) were higher in the PT-PE group as compared with the normotensive control group. Placental total cholesterol and HDL levels were higher (P < 0.05) in the T-PE as compared with the normotensive control group. Higher placental triglycerides (P < 0.05) were observed in PT-PE group compared with T-PE group. Placental mRNA levels of peroxisome proliferator activated receptor alpha, carnitine palmitoyl transferase-1, cluster of differentiation 36 and lipoprotein lipases were lower (P < 0.05) in the PT-PE than normotensive control group. A negative association of mRNA levels of peroxisome proliferator activated receptor alpha (r = -0.246, P = 0.032; r = -0.308, P = 0.007, respectively), carnitine palmitoyl transferase-1 (r = -0.292, P = 0.011; r = -0.366, P = 0.001), lipoprotein lipases (r = -0.296, P = 0.010; r = -0.254, P = 0.028) with SBP and DBP was observed. There was a positive association of placental triglycerides (r = 0.244, P = 0.031) with DBP. Conclusion: Women with preeclampsia exhibit higher lipid : lipoprotein ratios suggesting an atherogenic state particularly in women delivering preterm. Lower expression of genes involved in placental fatty acid oxidation and transport was also observed in preeclampsia.