Prostasomes, angiogenesis, and tissue factor
Prostasomes, angiogenesis, and tissue factor
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DOI：
10.1055/s-2006-958465
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发表时间：
2007-02-01
影响因子：
5.7
通讯作者：
Lwaleed, Bashir A.
中科院分区：
文献类型：
--
作者：
Delves, George H.;Stewart, Alistair B.;Lwaleed, Bashir A.
前列腺体是由前列腺上皮细胞产生的膜结合的分泌囊。众所周知，它们携带许多蛋白质，包括组织因子，并具有异常富含胆固醇和鞘磷脂的细胞膜。前列腺体在生育、促进精子活力、稳定顶体反应和促进免疫抑制等方面都有很好的效果。本文综述了前列腺体对体外血管生成实验影响的证据，以及这些影响发生的机制。精液前列腺体似乎抑制血管生成，而恶性前列腺细胞释放的等量颗粒促进血管生成。在这两种情况下，热处理后变性蛋白质含量的效果似乎保持不变，这表明了脂转移，特别是鞘磷脂转移的重要作用。
Prostasomes are membrane-bound secretory vesicles produced by prostatic epithelial cells. They are known to carry many proteins, including tissue factor, and have membranes unusually rich in cholesterol and sphingomyelin. Prostasomes have well-documented effects on fertility, promoting sperm motility, stabilizing the acrosome reaction, and facilitating immunosuppression. This article reviews the evidence of the effects of prostasomes on in vitro angiogenesis assays, and the mechanism by which these effects occur. Seminal prostasomes seem to inhibit angiogenesis, whereas the equivalent particles released by malignant prostate cells promote angiogenesis. In both cases, the effects seem preserved after heat treatment to denature the protein content, suggesting an important role for lipid transfer, in particular, transfer of sphingomyelin.