Curcumin attenuates allergen-induced airway hyperresponsiveness in sensitized guinea pigs
Curcumin attenuates allergen-induced airway hyperresponsiveness in sensitized guinea pigs
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DOI：
10.1248/bpb.26.1021
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发表时间：
2003-07-01
影响因子：
2
通讯作者：
Ghosh, B
中科院分区：
文献类型：
--
作者：
Ram, A;Das, M;Ghosh, B
姜黄素是姜黄根状茎的一种天然产物，其抗哮喘特性已在豚鼠气道高反应性模型中进行了测试。我们用卵清蛋白（OVA）致敏豚鼠，以发展哮喘的某些特征：过敏原诱导的气道收缩和气道对组胺的高反应性。豚鼠在致敏期间（以检验其预防作用）或出现气道受损特征后（以检验其治疗作用）给予姜黄素治疗。气道收缩和气道高反应性的状态是通过使用无创技术测量特定气道电导（SGaw）来确定的。姜黄素（20 mg/kg体重）显著抑制ova诱导的气道收缩(p
Anti-asthmatic property of curcumin (diferuloylmethane), a natural product from the rhizomes of Curcuma longa, has been tested in a guinea pig model of airway hyperresponsiveness. We sensitized guinea pigs with ovalbumin (OVA) to develop certain characteristic features of asthma: allergen induced airway constriction and airway hyperreactivity to histamine. Guinea pigs were treated with curcumin during sensitization (to examine its preventive effect) or after developing impaired airways features (to examine its therapeutic effect). Status of airway constriction and airway hyperreactivity were determined by measuring specific airway conductance (SGaw) using a non-invasive technique, constant-volume body plethysmography. Curcumin (20 mg/kg body weight) treatment significantly inhibits OVA-induced airway constriction (p