A peptide vaccine targeting angiotensin II attenuates the cardiac dysfunction induced by myocardial infarction.
A peptide vaccine targeting angiotensin II attenuates the cardiac dysfunction induced by myocardial infarction.
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DOI：
10.1038/srep43920
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发表时间：
2017-03-07
影响因子：
4.6
通讯作者：
Isobe M
中科院分区：
文献类型：
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作者：
Watanabe R;Suzuki JI;Wakayama K;Maejima Y;Shimamura M;Koriyama H;Nakagami H;Kumagai H;Ikeda Y;Akazawa H;Morishita R;Komuro I;Isobe M
血管紧张素II（angiotensin II，Ang II）肽疫苗是近年来发展起来的一种治疗高血压的新方法，可有效解决药物治疗的不依从性问题。血管紧张素Ⅱ在心肌梗死后心脏重构的发病机制中起着至关重要的作用，心肌梗死后心脏重构导致心力衰竭。在本研究中，我们研究了血管紧张素II疫苗是否能有效预防心力衰竭。在MI大鼠模型中注射Ang II疫苗可减轻心功能不全，并伴有血清抗Ang II抗体滴度升高。此外，在接受假手术的大鼠中未观察到Ang II疫苗的任何有害作用。注射Ang II疫苗大鼠的免疫血清治疗显著抑制MI大鼠的MI后心功能障碍和Ang II诱导的心脏成纤维细胞重塑相关信号传导。因此，我们目前的研究表明，血管紧张素II疫苗可能提供一个有前途的新的治疗策略，预防心力衰竭。
A peptide vaccine targeting angiotensin II (Ang II) was recently developed as a novel treatment for hypertension to resolve the problem of noncompliance with pharmacotherapy. Ang II plays a crucial role in the pathogenesis of cardiac remodeling after myocardial infarction (MI), which causes heart failure. In the present study, we examined whether the Ang II vaccine is effective in preventing heart failure. The injection of the Ang II vaccine in a rat model of MI attenuated cardiac dysfunction in association with an elevation in the serum anti-Ang II antibody titer. Furthermore, any detrimental effects of the Ang II vaccine were not observed in the rats that underwent sham operations. Treatment with immunized serum from Ang II vaccine-injected rats significantly suppressed post-MI cardiac dysfunction in MI rats and Ang II-induced remodeling-associated signaling in cardiac fibroblasts. Thus, our present study demonstrates that the Ang II vaccine may provide a promising novel therapeutic strategy for preventing heart failure.