Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi
Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi
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DOI：
10.1248/cpb.54.265
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发表时间：
2006-02-01
影响因子：
1.7
通讯作者：
Xu, HX
中科院分区：
文献类型：
--
作者：
Han, QB;Wang, YL;Xu, HX
从藤黄树脂中分离到13个口山酮（1 ~ 13）。其中，根据包括详细的二维核磁共振数据在内的广泛光谱证据，鉴定出2个新化合物（即gaudichadiic acid，和异伽马原酸，1,2）和1个新天然产物（deoxygaudichadione A, 3）。其中10个口山酮对人白血病K562 （K562/S）和耐阿霉素K562 （K562/R）细胞株的细胞毒性进行了测试，结果显示对两种细胞株的抑制作用相似，提示这组聚戊烯基化口山酮可能不是耐多药底物。
Thirteen xanthones (1-13) were isolated from the resin of Garcinia hanburyi. Among them, two new compounds (namely gaudichaudic acid, and isogambogenic acid, 1, 2), and one new natural product (deoxygaudichaudione A, 3) were identified on the basis of extensive spectral evidence including detailed 2D NMR data. Ten of these xanthones were tested for their cytotoxicities against human leukemia K562 (K562/S) and doxorubicin-resistant K562 (K562/R) cell lines, and showed similar inhibitory effects on both cell lines, suggesting that this group of polyprenylated xanthones might not be multidrug resistance (MDR) substrates.