Profiles in discouragement: Two studies of variability in the time course of smoking withdrawal symptoms
Profiles in discouragement: Two studies of variability in the time course of smoking withdrawal symptoms
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DOI：
10.1037/0021-843x.107.2.238
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发表时间：
1998-05-01
影响因子：
4.6
通讯作者：
Baker, TB
中科院分区：
文献类型：
--
作者：
Piasecki, TM;Fiore, MC;Baker, TB
研究表明，戒烟综合征的时间过程在吸烟者之间是相当不变的，戒烟症状与复发的关系很弱。分析了尼古丁贴片的2项临床试验的退出数据，以评价这些特征。在这两项研究中，患者根据8周治疗期间戒断曲线的形状进行聚类。在每项研究中，出现了3个具有不同时间模式的戒断症状群。集群包括禁欲和失效的患者，贴剂剂量与集群成员无关。具有“非典型”戒烟模式的患者（例如，晚期症状升高）比逐渐消除戒断症状的患者更容易复发。戒断形式、持续时间和严重程度均对复发的预测有显著影响。随着时间的推移，集群内的负面影响措施密切跟踪戒断症状。讨论了未来戒烟研究的主题。
Research has suggested that the time course of the smoking withdrawal syndrome is fairly invariant across smokers and that smoking withdrawal symptoms are weakly related to relapse. Withdrawal data from 2 clinical trials of the nicotine patch were analyzed to evaluate these characterizations. In both studies, patients were clustered according to the shapes of their withdrawal profiles across 8 weeks of treatment. In each study, 3 clusters with distinct temporal patterns of withdrawal symptomatology emerged. Clusters included both abstinent and lapsing patients, and patch dose was unrelated to cluster membership. Patients with "atypical" patterns of smoking withdrawal (e.g., late symptomatic elevations) were more likely to relapse than patients who showed a gradual elimination of withdrawal. Withdrawal shape, duration, and severity all contributed significantly to the prediction of relapse. Measures of negative affect closely tracked withdrawal symptoms over time within clusters. Topics for future smoking withdrawal research are discussed.