Association between insulin resistance and periodontitis in Korean adults
Association between insulin resistance and periodontitis in Korean adults
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DOI：
10.1111/jcpe.12196
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发表时间：
2014-02-01
影响因子：
6.7
通讯作者：
Park, Yong-Moon
中科院分区：
文献类型：
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作者：
Lim, Sang Gyu;Han, Kyungdo;Park, Yong-Moon
目的最近的研究表明牙周炎与代谢异常有关。我们调查了韩国成年人中胰岛素抵抗和牙周炎之间的关系。方法采用《2008-2010年韩国国民健康与营养调查》进行横断面分析。共有16,720名18岁以上的非糖尿病受试者被评估（7060名男性和9660名女性）。采用社区牙周指数评估牙周状况。胰岛素抵抗采用胰岛素抵抗稳态模型评估（HOMA-IR）进行测量。HOMA-IR最高和最低四分位数的参与者分别被定义为胰岛素抵抗和胰岛素敏感。结果绝经后妇女牙周炎患病率随着HOMA-IR四分位数的升高而显著增加（p为线性相关=0.019）。在绝经后妇女中，HOMA-IR最高四分位数的参与者患牙周炎的可能性明显高于最低四分位数的参与者[校正优势比（OR）， 1.47；95%置信区间（CI）， 1.07-2.01]。此外，肥胖绝经后妇女胰岛素抵抗和牙周炎之间的相关性增加（校正OR， 1.92; 95% CI,1.29-2.87）。然而，在男性或绝经前女性中没有发现这种关联。结论：胰岛素抵抗可能与韩国绝经后妇女牙周炎有关，尤其是与肥胖合并时。
ObjectiveRecent studies have proposed an association between periodontitis and metabolic abnormalities. We investigated the association between insulin resistance and periodontitis among Korean adults.MethodsA cross-sectional analysis was conducted using the Korea National Health and Nutrition Examination Survey 2008-2010. A total of 16,720 non-diabetic subjects over 18years old were evaluated (7060 men and 9660 women). Periodontal status was assessed by the Community Periodontal Index. Insulin resistance was measured using the homeostasis model assessment of insulin resistance (HOMA-IR). Participants in the highest and lowest quartile of HOMA-IR were defined as insulin-resistant and insulin-sensitive respectively.ResultsThe prevalence of periodontitis increased significantly with higher HOMA-IR quartiles in post-menopausal women (p for linear association=0.019). Among post-menopausal women, participants in the highest quartile of HOMA-IR were significantly more likely to have periodontitis compared to those in the lowest quartile [adjusted odds ratio (OR), 1.47; 95% confidence interval (CI), 1.07-2.01]. Moreover, obese post-menopausal women showed an increased association between insulin resistance and periodontitis (adjusted OR, 1.92; 95% CI,1.29-2.87). However, this association was not found in men or pre-menopausal women.ConclusionsOur results suggest that insulin resistance may be associated with periodontitis, especially when combined with obesity, among post-menopausal women in Korea.